Anti–vascular endothelial growth factor (anti-VEGF) therapies are effective treatment for severe diabetic retinopathy (DR) and macular edema, but a significant subset of people had inadequate response to anti-VEGF intervention. Because elevation or overexpression of retinol binding protein 3 (RBP3) decreases risks for retinal pathologies and progression to severe DR, we compared the therapeutic profiles of […]
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Clinical phenotyping of people living with type 1 diabetes according to their levels of diabetes-related distress: results from the SFDT1 cohort
Results We analyzed data from 1220 adults with type 1 diabetes in France, covering 39 diabetic centers (online supplemental figure S3). The mean age was 42.0 (SD 13.9) years, with average diabetes duration at 24.7 (13.6) years, and 617 (50.6%) were females. Among SFDT1 respondents, 775 (63.5%) used insulin pumps, of which 150 (19.4%) used […]
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What to Know About the Drug
Share on PinterestIn Season 3 of “The White Lotus,” some characters pop lorazepam like candy, highlighting the potential for dependency and misuse. CHANAKARN LAOSARAKHAM/AFP via Getty Images Lorazepam, a common anti-anxiety medication, makes frequent appearances in Season 3 of “The White Lotus” on HBO. This type of benzodiazepine used to treat anxiety, panic attacks, and […]
Read MoreRespiratory Vaccinations and Combating Vaccine Hesitancy in People With Diabetes–December 2024
In this special episode of Diabetes Core Update, our host, Dr. Neil Skolnik, discusses with two expert guests the recommendations for respiratory vaccinations in people with diabetes, the rise in vaccine hesitancy and some of the possible reasons for this hesitancy, and several ways to address vaccine hesitancy in the office. This special edition is sponsored […]
Read MorePadi4-Dependent NETosis Enables Diet-Induced Gut Hyperpermeability, Translating Dysbiosis Into Systemic Inflammation and Dysmetabolism
Microbial signals trigger the release of neutrophil extracellular traps (NETs) through peptidyl arginine deiminase 4 (PADI4). In turn, NETosis can propagate inflammation to distant tissues. We hypothesize that PADI4 mediates the interactions between diet-modified microbiota and host metabolism. We report that in the adipose tissue of individuals with obesity, NETosis was associated with dysglycemia. In […]
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Quantification of the relation between continuous glucose monitoring observation period and the estimation error in assessing long-term glucose regulation
Discussion This study provides the necessary analyses and specific information to guide decisions on the required measurement duration when estimating CGM-derived metrics. In contrast to some previous studies,3 6 7 12 the calculations were performed on individual patient data. That individual calculations can lead to different conclusions and decisions for individual patients, for example, within […]
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U.S. Measles Cases Approach 900 As Outbreak Expands to More States
Share on PinterestThe CDC reports that 97% of measles cases in the U.S. are in people who are unvaccinated or whose vaccination status is unknown. FG Trade/Getty Images The growing measles outbreak in the U.S. has reached 884 confirmed cases, surpassing the total number of cases in 2024. The CDC issued a measles advisory for […]
Read MoreDiabetes Core Update : Special Edition
In this special edition of Diabetes Core Update, host Neil Skolnik, MD, explores the timely and critical topic of compounded medications in diabetes care. Dr. Skolnik is joined by John Hertig, PharmD, MS, CPPS, Associate Professor at the Butler University College of Pharmacy and Health Sciences, and Ed Hernandez, Executive Vice President and President of […]
Read MoreCD40 Induces Unfolded Protein Response, Upregulation of VEGF, and Vascular Leakage in Diabetic Retinopathy
The unfolded protein response (UPR) drives events that promote diabetic retinopathy, including vascular endothelial growth factor (VEGF) upregulation in Müller cells. How UPR is activated in vivo in the diabetic retina is not well understood. CD40 is required for development of diabetic retinopathy, but whether CD40 mediates activation of UPR sensors is unknown. CD40 ligation in […]
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Diabetes in migrant communities: a rising healthcare priority
As of 2023, an estimated 281 million people globally are international migrants—constituting approximately 3.6% of the world population, reflecting steady growth over the past years.1 Non-communicable diseases, including diabetes, disproportionately impact migrant and ethnic minority populations due to a combination of genetic, environmental and socioeconomic factors.2 Previous studies in the USA and Europe have shown that […]
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