Introduction and Objective: We explored whether and how depressive symptoms in youth and young adults (YYA) with youth-onset type 1 diabetes (T1D) mediate the effects of household food insecurity (HFI) on hemoglobin A1c (HbA1c).Methods: Cross-sectional data from the SEARCH for Diabetes in Youth Study (2016-2019) included 1,093 YYA with T1D. We applied causal mediation modeling […]
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1213-P: Correlation of Home Monitoring and In-Clinic C-Peptide Values in Patients with New-Onset Type 1 Diabetes
Introduction and Objective: Understanding factors associated with C peptide (CP) preservation in type 1 diabetes (T1D) may aid interventions in the partial remission period. Fasting and stimulated CP or urinary CP to creatinine ratio (UCPCR) measure residual beta cell function.Methods: We utilized home monitoring CP collection with volumetric absorptive microsampling (VAMS) and a simplified mixed […]
Read More54-OR: Insulin Stabilized Arterial Plaques by Regulating Vascular Smooth Muscle Differentiation
Introduction and Objective: Risk of unstable plaques, noted by reduced content of vascular smooth muscle cells (VSMC) and extracellular matrix (ECM), with elevated inflammatory cells and necrosis, are increased in diabetes for unknown reasons. This study investigated the role of insulin in VSMC and the formation of unstable plaques.Methods: Insulin receptor (IR) knockout and VSMC […]
Read More1212-P: Anthropometric Trends in Children with T1DM Onset over a Three-Year Follow-up—A Case Control Study across Latin American Centers
Introduction and Objective: Children with T1DM may experience alterations in growth. The aim was to compare growth trajectories assessed by z-Height and z-BMI over three years between children with new-onset T1DM and a control group without T1DM across multiple Latin American centers.Methods: In a retrospective analysis of medical records, age, sex, and anthropometric measures were […]
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Why Rob Lowe Wants More People to Join Cancer Clinical Trials
Share on PinterestActor Rob Lowe has teamed up with Eli Lilly to encourage more people to participate in cancer clinical trials. Photography courtesy of Rob Lowe Rob Lowe shares how three generations of women in his family passed away from breast cancer. The acclaimed actor has partnered with Eli Lilly to spread awareness about the […]
Read More362-OR: Morning Elevation in Insulin Enhances Afternoon Postprandial Insulin Action and Glucose Effectiveness
Introduction and Objective: The 2nd meal phenomenon refers to the improved glycemic response observed after consuming a 2nd identical meal. It is well known that postprandial hepatic glucose uptake (HGU) is determined by the combined effects of three regulatory factors: insulin action (hyperinsulinemia; HI), glucose effectiveness (hyperglycemia; GE), and glucose delivery into the hepatoportal circulation […]
Read More1211-P: Screening for Disordered Eating Behaviors in Youth with Type 1 Diabetes and the Impact of Using the Advanced Diabetes Technologies—Feasible and Needed
Introduction and Objective: We implemented Disordered eating behaviors (DEB) screening in adolescents with type 1 diabetes (T1D) using the Diabetes Eating Problem Survey-Revised (DEPS-R) tool as recommended by the American Diabetes Association. We aim to highlight the prevalence of DEB in adolescents with T1D along with the relationship with technology use.Methods: Retrospective chart review of […]
Read More1176-P: Short-Term Reproducibility of i3C Risk Score in Predicting Cardiac Events in Young People
Introduction and Objective: Cardiovascular disease (CVD) is the leading cause of death in the US. The i3C risk score is the only predictive model of 35-year fatal/non-fatal cardiac events in adolescents and young adults (AYA), but its reliability is unknown. We evaluated the i3C score test-retest reproducibility over short and long-term intervals.Methods: In a pooled […]
Read More819-P: Efficacy and Hypoglycemia Outcomes with Once-Weekly Insulin Icodec vs. Once-Daily Basal Insulin in T2D by Baseline BMI—ONWARDS 1–5
Introduction and Objective: This post hoc analysis assessed the efficacy and hypoglycemia outcomes with once-weekly insulin icodec (icodec) vs once-daily (OD) basal insulin comparators in insulin-naive (ONWARDS 1, 3, 5) and insulin-experienced (ONWARDS 2, 4) adults with T2D by baseline BMI.Methods: Treatment outcomes were analyzed, by trial, across baseline BMI subgroups (<25, ≥25-<30, ≥30-<35, ≥35 […]
Read More1018-P: GluVue: Revolutionizing Continuous Glucose Monitoring Data Interpretation in Clinical Practice
Introduction and Objective: GluVue is a free application designed to enhance the efficiency of continuous glucose monitoring (CGM) data analysis for healthcare providers. Its primary goal is to improve clinical workflows and patient care in diabetes management.Methods: GluVue is designed to integrate seamlessly with electronic health records (EHR) and provide real-time analysis of continuous glucose […]
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