Author: sugaradmin

Introduction and Objective: The prevalence of PD and T2D has been steadily increasing. Thus, early risk markers for PD and T2D in individuals with NG are critically important. We asked whether Insulin Resistance Risk Score (IRRS) could be an early risk marker for future PD or T2D.Methods: Individuals with NG (FPG <100 mg/dL and HbA1c […]

Introduction and Objective: The global prevalence of type 2 diabetes mellitus (T2DM) is widely recognized to be on the rise. It is of great significance to reveal the current status of antidiabetic therapy in patients with T2DM.Methods: “Real-world Multicenter Registry to Determine Management and Quality of Care of Patients With Type 2 Diabetes in China” […]

Introduction and Objective: Hyperglycaemia has emerged as a significant complication in COVID-19, particularly in India, where the prevalence of diabetes is high. The objective of this study was to determine the prevalence, clinical manifestations, severity, and outcomes of new-onset hyperglycaemia in COVID-19 patients without pre-existing diabetes.Methods: A retrospective observational study was conducted on 2750 hospitalised […]

Introduction and Objective: Incretin drugs effectively promote weight loss, but also cause inevitable lean mass loss, compromising weight loss quality (WLQ). Urocortin-2 (UCN2) shows potential for enhancing lipolysis and muscle hypertrophy, offering a strategy to improve WLQ. To achieve these outcomes, a novel corticotropin-releasing factor receptor-2 (CRFR2) selective UCN2 analog, HM17321, was developed. The present […]

Introduction and Objective: This study aimed to evaluate the feasibility of a community-supported initiative for diabetes screening and management in a rural community in Bangladesh.Methods: Our community-supported initiative comprised design ethnography to understand the community and identify local resources. Then, community organization was facilitated by forming a health and inclusion committee after obtaining approval from […]

Introduction and Objective: Rare loss-of-function mutations in the DYRK1B gene are associated with early-onset coronary artery disease, metabolic syndrome, and type 2 diabetes.Methods: To investigate its role in metabolism, we generated global Dyrk1b knockout (KO) mice and conducted detailed metabolic and cellular analyses.Results: IPGTT, ITT, and plasma insulin and C-peptide in adult mice revealed impaired […]

Introduction and Objective: Nucleotide-binding oligomerization domain 1 (Nod1), an immune receptor, drives fat-induced insulin resistance. Recent studies show that whole-body and hematopoietic Nod1 knockout (KO) protect against insulin resistance. However, it remains uncertain whether the effect in whole-body KO is due to Nod1 deficiency in macrophages or in extra-macrophage cell(s). Nod1 is expressed in insulin-sensitive […]

Introduction and Objective: Gastric bypass surgery (GB) is a treatment for obesity but alters prandial glycemia, increasing the risk of hypoglycemia. Glucagon administration is a potential therapy for post-GB hypoglycemia, but its effects on prandial glycemia or symptoms remain unclear. We investigated the effect of intravenous (IV) glucagon on prandial symptoms in subjects with and […]

Introduction and Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent in people with type 2 diabetes (T2D). MASLD screening is now recommended through calculation of the fibrosis-4 index (FIB4), derived from age, platelet count, AST, and ALT. We evaluated the rate at which these markers were obtained within 2 years for patients with […]