Author: sugaradmin

Introduction and Objective: MiniMedTM 780G (MM780G) advanced hybrid closed loop (AHCL) therapy with the Guardian™ 4 sensor demonstrated significantly improved A1C, increased time in range (%TIR, 70-180mg/dL) and tight range (%TITR, 70-140mg/dL), with no increase in time below range (%TBR, <70mg/dL), in PwT2D.1 Herein, we report on system use with the new, disposable, all-in-one Simplera […]

Introduction and Objective: CGM is standard of care for people living with T1D; barriers to sustaining CGM use persist. Less is known about factors leading to non-use following initial CGM uptake.Methods: This qualitative study explored experiences of adults (ages 18-50) with T1D in a CGM uptake randomized controlled trial who received 3 months of CGM […]

Introduction and Objective: Cellular senescence is a stress response marked by the upregulation of antiapoptotic pathways, loss of function, and secretome remodeling (SASP). Pancreatic β-cells undergo senescence with age and insulin resistance, while their targeted removal improves glucose homeostasis, demonstrating the role of β-cell senescence in diabetes progression. However, β-cell senescence can also promote β-cell […]

Introduction and Objective: Type two diabetes (T2D) is a leading cause of chronic renal disease (CKD). Despite strong links between T2D, CKD, and cardiovascular disease (CV), the incidence and timing of major arrhythmias in this high-risk population remains unclear. This study examines the incidence, timing, and risk associated with major arrhythmias in T2D-CKD patients.Methods: We […]

Introduction and Objective: Insulin pumps are beneficial for people with type 1 diabetes (T1D). However, the time required to initiate pump therapy after the decision to start remains unclear. This study quantifies the time from decision to pump start (TTPS).Methods: This retrospective study included individuals with T1D at an academic diabetes center who decided to […]

Introduction and Objective: Aryl hydrocarbon receptor (AHR) serves as a crucial molecular pathway that is regulated by both endogenous and environmental small molecules to shape the immune response and contribute to the onset of autoimmune diseases. AHR also offers a potential target for therapeutic intervention in immune-mediated disorders. Tryptophan metabolite ITE functions as an endogenous […]

Introduction and Objective: This study examines changes in treatment satisfaction and glycemic outcomes in people with type 1 diabetes (PwT1D) transitioning from multiple daily injections (MDI) to continuous subcutaneous insulin infusion (CSII) with the tubeless Accu-Chek Solo micropump.Methods: CSII-naive PwT1D from Argentina (n=50) were enrolled in a multi-center, prospective, single-armed study using Accu-Chek Solo with […]

Introduction and Objective: We aimed to identify candidate placental proteins that impact beta-cell function in human pregnancy through transcriptome-wide placental gene expression analysis.Methods: In the Gen3G cohort, we measured glucose and insulin levels fasting, 1, and 2 hours after a 75-gram oral glucose load given at 24-30 weeks’ gestation. We calculated the Pregnancy Insulin Physiology […]

Introduction and Objective: SGLT2 inhibitors are efficacious in patients with T2D, renal dysfunction, and heart failure; yet their use in patients with T1D is limited due to increased risk of DKA despite demonstrating improvement in A1c and percent glucose time in range. To understand the molecular basis of SGLT2i-mediated DKA risk, we performed comprehensive plasma […]

Introduction and Objective: Erythropoietin (EPO), a glycoprotein cytokine primarily produced in the kidneys in response to hypoxia is required for erythrocyte production, promotes erythroid differentiation and increases glucose uptake in erythroid progenitor cells in culture. The discovery that its receptor (EPOR) is expressed on both hematopoietic and non-hematopoietic tissues has led to research expanding our […]