Author: sugaradmin

Introduction and Objective: The sarco-ER Ca2+ ATPase (SERCA2) pump maintains endoplasmic reticulum (ER) Ca2+ levels in the pancreatic β-cell. Previously, we demonstrated reduced SERCA2 expression in islets from human organ donors with type 2 diabetes (T2D) compared to islets from non-diabetic organ donors. Additionally, we have shown that heterozygous deletion of SERCA2 in mice (S2HET) […]

Introduction and Objective: White adipose tissue (WAT) insulin resistance (IR) is essential to the pathogenesis of metabolic disease; yet defects in human WAT insulin signaling are not well characterized. This study elucidates alterations to WAT insulin signaling associated with human IR.Methods: Human WAT was obtained from three cohorts of patients with obesity: 1) in a […]

Introduction and Objective: Hypoleptinemia is a potent orexigenic signal. Ethanol (EtOH) consumption is associated with weight gain in humans, and acute ethanol treatment leads to reductions in leptin levels in both fasted humans and rats. The objective of this study was to determine whether the route of administration or treatment in the fed or fasted […]

Introduction and Objective: Diabetes and obesity affect millions of individuals in the United States leading to significant morbidity and mortality. Obesity, major driver for diabetes development, is characterized by insulin and leptin resistance. We previously showed that loss of Gpr17 in selective hypothalamic neurons and intestine led to better energy balance and glucose metabolism. Our […]

Introduction and Objective: Studies report that COVID-19 illness increases diabetes risk, but the clinical course of incident diabetes following COVID-19 illness is unknown. We compared the course of new onset diabetes in American Indian and Alaska Native people with and without evidence of prior COVID-19 illness.Methods: We used de-identified patient data from the Indian Health […]

Introduction and Objective: Our previous studies demonstrated that a telehealth-supported Community Health Worker (CHW) intervention significantly improved clinical outcomes in diabetes care. However, the extent to which these benefits vary across different age groups remains unclear.Methods: The aim of this study was to assess the effectiveness of the intervention in changing HbA1c across different age […]

Introduction and Objective: The success of longitudinal studies depends on the retention of participants. We examined sociodemographic, clinical and psychosocial characteristics as predictors of retention among participants with prediabetes and type 2 diabetes (T2D) in the DPP/DPPOS.Methods: 3218 adults who joined the DPP (1996-1999, mean age 51±10y) at high risk of T2D were randomized to […]

Introduction and Objective: CD40 promotes autoimmune inflammation. Current therapeutic approaches are monoclonal antibodies. We designed a 15-amino acid peptide targeting the CD40 receptor.Methods: We treated autoimmune canine diabetes mellitus (CDM) and human T1DM subjects with the peptide. CDM were treated with 2 mg/kg by IV or subcutaneous injection (Sub-Q) for up to 18 months. A […]

Introduction and Objective: We aimed to characterize the long-term changes using body mass index (BMI) time in target range (TTR) and test its independent association with all-cause and cardiovascular mortality.Methods: This study included 3524 patients (58% men) aged 40-80 years with at least 3 BMI measurements within 4 years since their first inpatient diagnosis of […]

Introduction and Objective: Insulin gene (INS) variants are a rare cause of monogenic diabetes, with clinical presentations including (1) permanent or transient neonatal diabetes and (2) adolescent or adult-onset diabetes sometimes referred to as maturity onset diabetes of the young (INS-MODY/MODY10). Here we report four previously undescribed INS variants in individuals with atypical adult-onset diabetes.Methods: […]