Introduction and Objective: In general population screening for type 1 diabetes (T1D), large proportion of islet autoantibodies (IAbs) detected by the standard radio-binding assay (RBA) are not predictive due to low-affinity. Electrochemiluminescence (ECL) IAb assay has been shown in multiple studies to improve predictive accuracy by detecting high-affinity IAbs. Our new bridging ELISA for insulin […]
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Increasing Protein Intake Could Help Prevent Muscle Loss
Share on PinterestNew research suggests that eating more protein while taking GLP-1 drugs could help prevent muscle loss. Stocksy United Increasing protein intake while taking GLP-1 drugs for weight loss could help prevent muscle loss, according to a new study. As a common side effect of weight loss, muscle loss could also lead to decreased […]
Read More2178-LB: BI-4659, an Adipose Tissue–Enriched Mitochondrial Uncoupler, Reverses Diet-Induced Obesity in Mice
Introduction and Objective: Obesity presents a major global health concern with increasing prevalence worldwide. Currently, GLP-1 based therapies present the most effective treatment for obesity, but their tolerability and efficacy are limited by gastrointestinal side effects and compensatory reduction in energy expenditure (EE). Mitochondrial uncoupling by protonophores was shown to increase EE and reduce body […]
Read More1154-P: Increasing Awareness and Identification of Maturity-Onset Diabetes of the Young (MODY) in a Pediatric Diabetes Clinic
Introduction and Objective: MODY is frequently misdiagnosed, but accurate diagnosis can afford alternate management options. Prevalent barriers to MODY identification include lack of familiarity with MODY testing guidelines and insurance denial for testing. We launched a quality improvement (QI) project in 2022 at a pediatric, tertiary care center which aimed to: (1) increase the number […]
Read More2177-LB: Mitochondrial Infiltration of Nuclear-Derived circRNA circBirc6 Regulates ATP Synthase Assembly and Fat Differentiation, Linking Energy Metabolism to Obesity
Introduction and Objective: Impaired adipocyte differentiation contributes to insulin resistance and obesity-related type 2 diabetes. Mitochondrial dysfunction is central to impaired adipogenesis. This study investigates how nuclear-encoded circRNA circBirc6 regulates mitochondrial function and adipogenesis, and its role in metabolic disorders.Methods: We used obesity and adipose-specific circBirc6 knockdown mouse models, and clinical samples from obese and […]
Read More1092-P: Interim Analysis of a Multicenter, Randomized Controlled Trial—Insights from Technology-Enabled Platform for Glycemic Control in Type 2 Diabetes (T2D)
Introduction and Objective: T2D presents significant challenges to health outcomes, necessitating effective strategies to optimize glycemic levels. This study examines the impact of tech empowered personalized lifestyle coaching, encompassing diet, fitness, and mental wellness, on improving glycemic control in T2D.Methods: This interim analysis was conducted on 34 participants (HbA1c >8%) compared the test group (n=18) […]
Read More2176-LB: Circadian Clock Regulation of HIF1a-Dependent Skeletal Muscle Metabolism during Diet-Induced Obesity
Introduction and Objective: Epidemiological and genetic studies have shown that disruption of circadian rhythms leads to accelerated and worsened symptoms of metabolic syndrome. Studies indicate that core clock factor, BMAL1, is required for insulin-dependent skeletal muscle glucose uptake in lean mice. However, the role of the clock in skeletal muscle metabolism during metabolic stress is […]
Read More1471-P: Impact of SGLT2 Inhibitors with ARB or ACE Inhibitors on Cardiorenal Outcomes in Type 2 Diabetes without Preexisting Cardiovascular or Renal Disease
Introduction and Objective: The cardio-renoprotective properties of sodium-glucose cotransporter-2 (SGLT-2) inhibitors, angiotensin receptor blockers (ARBs), and angiotensin-converting enzyme (ACE) inhibitors are well-documented; however, their effectiveness in primary prevention among individuals with diabetes mellitus and hypertension, without preexisting cardiovascular (CV) or kidney disease, remains uncertain. This study evaluates the potential synergistic benefits of combining SGLT-2 inhibitors […]
Read More2175-LB: Pathological Reprogramming of Adipose Tissue Mesenchymal Cells in Obesity and Metabolic Diseases
Introduction and Objective: Adipose tissue (AT) is a central regulator of energy homeostasis and systemic metabolism. Dysfunctional AT expansion during obesity is a major driver of metabolic diseases, particularly type 2 diabetes. Mesenchymal progenitor cells (MPCs), a heterogeneous and dynamic cell population, play a critical yet poorly understood role in AT expansion and function. In […]
Read More836-P: Glucagon-Like Peptide 1 Receptor Agonists Use during Ramadan Fasting in People with Type 1 Diabetes—Observational Study
Introduction and Objective: The American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) recommend glucagon-like peptide-1 receptor agonists (GLP1-RA) for type 2 diabetes, but their use in type 1 diabetes (T1D) is limited. This study compared glycemic metrics and adverse events in fasting and non-fasting people with T1D using GLP1-RA during […]
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