Author: sugaradmin

Introduction and Objective: Virtual diabetes management platforms can be used to improve glycemic control for people with diabetes. The objective of this study was to evaluate the effectiveness of the Diabetes Care Management coaching program in the Wellworks for You© (WW) chronic disease management virtual platform.Methods: A cohort of people with diabetes enrolled in the […]

Introduction and Objective: Body mass index (BMI), weight adjusted for height, is an imprecise tool for the diagnosis of obesity. Body composition assessment with bioelectric impedance analysis (BIA) scales estimate fat mass and % adiposity, offering a more precise diagnosis of obesity. The objective of this project was to compare the use of BMI and […]

Introduction and Objective: T1D management may require frequent interventions which disrupt the school day, though the missed class time and impact on students are not described. We aimed to determine the frequency, duration, and type of school disruptions for students with T1D.Methods: We analyzed data for 16 children (age 9.0±1.8 years, 62% female, 31% public […]

Introduction and Objective: This cost analysis compared FreeStyle Libre® systems (FSL) vs self-monitoring of blood glucose (SMBG) in T2D patients on basal insulin and poorly controlled (HbA1c > 8%), from a societal perspective in Spain.Methods: A model compared costs (€2024) of FSL and SMBG in a cohort of 1,000 T2D patients. The inputs, validated by […]

Introduction and Objective: Diabetes mellitus (DM) is a chronic condition characterized by elevated blood glucose levels due to insufficient insulin production or ineffective utilization. DM often coexists with thyroid diseases, particularly hypothyroidism, which can impact glycemic control and increase the risk of complications. Thyroid replacement therapy, typically with levothyroxine, is crucial for managing hypothyroidism in […]

Introduction and Objective: The main estrogen (17β-estradiol, E2) enhances insulin biosynthesis and secretion, protecting both female (F) and male (M) β-cells from metabolic stresses via the estrogen receptor-α (ERα). E2 activates unfolded protein degradation pathways, mitigating endoplasmic reticulum (EndRet) stress in human and mouse islets. However, the FDA-approved selective estrogen receptor modulator (SERM) bazedoxifene (BZA) […]

Introduction and Objective: T2D complications manifest across various organs, but are fundamentally rooted in vascular dysfunction, including fibrosis, inflammation, calcification and endothelial damage. Much of complication heterogeneity arises from variation in angiostructures (e.g., larger vessels vs. smaller capillaries) and how they are impacted by elevated glucose levels. This study aims to identify mechanisms underlying macro- […]

Introduction and Objective: Chromatin-associated regulatory RNAs (carRNAs), including promoter- and enhancer-associated RNAs, are known regulators of global gene transcription, yet the regulation of carRNAs remains poorly understood. Recent studies implicate RNA N6-methyladenosine (m6A) modification in carRNA stability and function. Seminal work from our lab has shown that m6A “writers” (e.g., methyltransferase-like 3 (METTL3) and METTL14) […]

Introduction and Objective: Structured education for type 1 diabetes (T1D) aims to empower individuals to manage their condition effectively. However, limited research has explored the long-term effects of structured education on glycemic improvement, severe hypoglycemia, or diabetic ketoacidosis (DKA). This study assessed the 12-year impact of dose adjustment for normal eating (DAFNE) courses on glycemic […]