Author: sugaradmin

Introduction and Objective: Metals may increase the risk of GDM, while certain elements may be protective. We examined the associations of a mixture of metals and elements during pregnancy with GDM risk in a predominantly Black and Hispanic cohort.Methods: In the Boston Birth Cohort, we measured Pb, Hg, Cd, Se, and Mn in maternal red […]

Introduction and Objective: Low carbohydrate diets (LCDs) are used by some living with T1D due to perceived glycemic benefits. Yet, few randomized controlled trials have studied LCDs in youth with T1D.Methods: Youth (12-25y) with T1D enrolled in a randomized crossover study to follow a LCD (<15% calories from carbs) and a standard carbohydrate diet (SCD, […]

Introduction and Objective: C414A-CRY1 transgenic mice (TG) develop diabetes due to SASP-like phenotypes in β-cells. We demonstrated that mucinous intra-islet ductal cells (IIDCs) expressing TFF2, that is known as a marker of spasmolytic polypeptide-expressing metaplasia (SPEM) in the stomach, emerge age-dependently in TG. Reportedly, acinar to ductal metaplasia (ADM) occurs through a process similar to […]

Introduction and Objective: Residing in disadvantaged neighborhoods is linked to negative health outcomes. We aimed to assess if neighborhood disadvantage, measured by the area deprivation index (ADI), predicts glycemic outcomes and development of complications in youth-onset type 2 diabetes (T2D).Methods: We extracted data from 2014-2024 from the University of California (UC) Health Data Warehouse which […]

Introduction and Objective: Little is known regarding cannabis (THC) and alcohol (EtOH) use in young adults with T1D.Methods: In this cross-sectional study, participants 18-26 years old with T1D in a pediatric clinic were asked study-designed questions to assess THC and EtOH use and knowledge of their glycemic impacts. Respondents were classified by THC and EtOH […]

Introduction and Objective: Adipose tissue (AT) immunoregulatory T cells (Tregs) are major determinants of systemic metabolism. In the lean phenotype, Tregs protect against inflammation and maintain homeostasis in AT. However, their abundance profoundly decreases in obesity, leading to inflammation, insulin resistance, and other inflammation-driven comorbidities. The transcription factor forkhead box protein P3 (Foxp3) is essential […]

Introduction and Objective: Guidelines endorse CGM use during hospitalizations with proper support. However, barriers and facilitators for optimal implementation in the pediatric hospital setting are unknown. We aimed to evaluate user experiences before and after implementing a pediatric hospital CGM policy.Methods: In September 2024, we implemented a hospital policy to support using personal CGM to […]

Introduction and Objective: AI-driven glucose predictions help CGM users manage glucose levels more proactively. The Accu-Chek® SmartGuide Predict app notifies of low glucose levels within 30 minutes (LGP), nighttime hypoglycemia risk (NLP), and provides a continuous 2-hour glucose forecast (GP). This study evaluates the potential glycemic benefits of the app via in-silico analysis.Methods: Using UVa’s […]

Introduction and Objective: Gestational diabetes mellitus (GDM) risk varies by area and is potentially associated with social disparity and variation in the built environment. There remains limited evidence examining the association between socio-ecological factors and GDM risk. This study examined the association between socio-ecological factors and GDM risk at local area level over time in […]

Introduction and Objective: SGLT-2 inhibitors (SGLT-2i) reduce heart failure (HF) hospitalization among HF patients and slow kidney disease progression and lower cardiovascular risk among patients with chronic kidney disease (CKD). We estimated the proportion of patients with type 2 diabetes and either HF or CKD with an active prescription for an SGLT2i and identified factors […]