Author: sugaradmin

Introduction and Objective: Cardio-renal complications are the leading source of morbidity in people with type 1 diabetes (T1D). While previous metabolomic studies have characterized incident and predictive metabolic signatures (metabotypes) of diabetic kidney disease (DKD) and cardiovascular autonomic neuropathy (CAN) in separate T1D cohorts, no previous study has investigated CAN and DKD in the same […]

Introduction and Objective: Sugar-sweetened beverages (SSBs) consumption has emerged as a critical public health concern globally. However, comprehensive analysis of its long-term impact on diabetes mellitus and chronic kidney disease (CKD) mortality across different socio-demographic contexts remains limited.Methods: Using Global Burden of Disease Study 2021 data, we analyzed SSB-attributable diabetes and CKD mortality trends across […]

Introduction and Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) with diabetes has grave health implications. The FAST score is a widely used tool for assessing MASLD severity. However, its relationship with indices such as TyG INDEX, TyGWHtR, BMI, and WHtR remains unclear. This study evaluated the predictive value of these indices for MASLD severity using […]

Introduction and Objective: Diabetic Kidney Disease (DKD) occurs commonly in people with diabetes and often presents with albuminuria resulting from glomerular filtration barrier injury. The glycocalyx, an extracellular matrix (ECM) produced by endothelial cells, plays a critical role in regulating glomerular filtration.Methods: To test if diabetes induces ECM changes, we examined the abundance of glomerular […]

Introduction and Objective: To explore the incidence of emergency hospitalization among young-onset diabetes using a nationwide registry database.Methods: Based on the Korean National Health Insurance Service-National Sample Cohort database from 2006 to 2019, data were collected for patients aged ≤30 years with type 1 (T1D) and type 2 diabetes (T2D). The risks of emergency hospitalization […]

Introduction and Objective: Individuals who carry genetic variants that lower A1C independently of glycemia may have undetected hyperglycemia. Other glycated proteins can be used as alternate glycemic measures but whether these A1C variants affect their levels is unclear.Methods: We recalled 202 patients (10% diabetes) from the Mass General Brigham Biobank enriching recruitment for the African […]

Introduction and Objective: Large-scale, real-world data on age- and sex-specific Level 3 hypoglycemia rates in type 1 or 2 diabetes (T1D, T2D) remain critically sparse. We aimed to address this gap using prospective data from the iNPHORM study.Methods: Adults (≥18 years) with T1D or T2D on insulin and/or secretagogues recruited from a US-wide probability-based internet […]

Introduction and Objective: Managing carbohydrate intake and physical activity (PA) are recommended for individuals with pregnancy hyperglycemia, but the concurrent impact of these behaviors and meal timing on postprandial glucose levels has not been explored.Methods: Fourteen participants with gestational glucose intolerance (GGI) and 2 with GDM from the Time to Move Randomized Crossover Trial (ClinicalTrials.gov […]

Introduction and Objective: Glycated hemoglobin (HbA1c) is the primary clinical measure of average glucose (AG). The X-linked G6PD variant has been associated with lower HbA1c but higher complication risks; yet the extent to which the variant impacts the HbA1c-AG relationship resulting in undetected hyperglycemia is unclear.Methods: In the GRADE Study, 1287 participants with type 2 […]

Introduction and Objective: Extracellular vesicles (EVs) are small membrane-bound particles secreted by cells, playing a crucial role in intercellular communication and cellular homeostasis.Methods: Human EndoC βH1 beta cells were obtained from Human Cell Design. To assess impacts of EV transfer on recipient cells, small EVs from cells treated with or without a cytokine mix were […]