Author: sugaradmin

Introduction and Objective: Offloading is a cornerstone of diabetic foot ulcer management, yet uncertainty remains regarding the comparative effectiveness of available offloading modalities. The objective of this study was to compare clinical outcomes associated with offloading strategies for diabetic foot ulcers.Methods: We performed a meta-analysis of studies evaluating offloading modalities for diabetic foot ulcers. Included […]

Introduction and Objective: National CEDER offers free services to researchers and community groups on community-engaged type 2 diabetes (T2D) programming and research. We assess client satisfaction with CEDER services and early indicators of change of capacity following the first year of services (9/2024-8/2025).Methods: Clients received REDCap survey links via email. Post-service surveys were sent immediately […]

Introduction and Objective: Protein lactylation is implicated in MASLD, yet its functional role remains poorly defined. This study investigated the mechanism through which AARS2 regulates SOD2 lactylation to drive MASLD progression.Methods: This study integrated multi-omics data from clinical and preclinical MASLD models to systematically assess AARS2 expression. Lactyl-proteomics identified SOD2 as a key target. Direct […]

Introduction and Objective: Social needs (SNs), such as food insecurity and unstable housing, heighten risk for type 2 diabetes (T2D) and limit engagement in prevention efforts. Latino communities experience disproportionately high rates of both SNs and T2D. Although SNs influence diabetes risk and prevention, little is known about how organizations delivering T2D prevention programs address […]

Introduction and Objective: The impact of glycemic variability (GV) on muscle mass in Type 2 diabetes mellitus (T2DM) remains unclear under the updated Asian Working Group for Sarcopenia (AWGS) 2025 criteria. We investigated the association between continuous glucose monitoring (CGM)-derived GV and low skeletal muscle mass (LSMM).Methods: This cross-sectional study included 614 hospitalized T2DM patients […]

Introduction and Objective: KAT8 (lysine acetyltransferase 8), also known as MOF or MYST1, acetylates diverse protein substrates to regulate multiple cellular processes. Although KAT8 is expressed in adipocytes and adipose tissue, its function in adipocytes is unknown. We previously generated a mouse model with adiponectin-expressing cell-specific deletion of KAT8 (KAT8AKO) and found that these mice […]

Introduction and Objective: The risk of hypoglycemia increases with age and medical complexity. Recent trends in the epidemiology of hypoglycemia among older adults with diabetes have not been previously evaluated.Methods: We conducted an annual repeated cross-sectional cohort study from 2017-2024 in Epic Cosmos, a nationwide database of electronic health records of more than 300 million […]

Introduction and Objective: Innate immune signaling is a key driver of diabetic nephropathy (DN). We previously showed that diabetes-induced expression of the stress protein REDD1 contributes to proinflammatory signaling in podocytes. The objective of this study was to determine if therapeutic suppression of REDD1 in podocytes was sufficient to mitigate renal inflammation in diabetic mice.Methods: […]

Introduction and Objective: Calcium is a key regulator of insulin secretion; yet, regulation of mitochondrial calcium handling is understudied in pancreatic β-cells. Here, we assessed whether mitochondrial calcium (mtCa2+) overload by deletion of the mitochondrial sodium-calcium exchanger (NCLX) in β-cells is sufficient to perturb glucose homeostasis in vivo. Given that mitochondrial metabolic activity is calcium-dependent, […]

Introduction and Objective: GDF8 and activin A signal through the activin typeII receptor ActRIIA and ActRIIB to limit muscle growth. However, the specific role of each ActRII at regulating muscle mass remains to be elucidated. Here we pharmacologically interrogate the function of ActRIIA and ActRIIB using human myoblast differentiation model which is highly predictive of […]