Author: sugaradmin

Introduction and Objective: Immune-mediated rejection remains a major barrier to durable pancreatic islet transplantation for type 1 diabetes. Mesenchymal stromal/stem cells (MSCs) possess immunomodulatory properties, and engineering MSCs to overexpress alpha-1 antitrypsin (AAT) may enhance their therapeutic potential. This study evaluated whether co-transplantation of human islets with AAT-overexpressing MSCs (AAT-MSCs) improves graft survival and modulates […]

Introduction and Objective: T1D-CATCH (Collaboration Around Technology using Community Health Workers) was a hybrid effectiveness-implementation randomized trial evaluating a 6-month CHW intervention to increase diabetes technology use among high-risk young adults with T1D. Co-designed with young adults and providers, the intervention aimed to reduce provider burden and deliver patient-centered technology support. This report focuses on […]

Introduction and Objective: Excessive diabetes device alerts can be burdensome for people with diabetes. Frequent autocorrection boluses inherent to the MiniMed™ 780G (MM780G) system are shown to reduce nighttime (SG) alarms/alerts.1 The present study assessed SG alarm/alert burden and glycemia in system users with and without optional SG alerts on.Methods: Deidentified CareLink™ data (01FEB2025 to […]

Introduction and Objective: Skeletal muscle plays a central role in whole-body lipid metabolism through mitochondrial and peroxisomal fatty acid oxidation (FAO). When skeletal muscle lipid metabolism is impaired, whole-body adaptations occur to maintain metabolic homeostasis. We hypothesized that limiting skeletal muscle lipid metabolism through mitochondria &/or peroxisomes would trigger adaptive responses to reduce dietary lipid […]

Introduction and Objective: RNA modifications are crucial regulators of gene expression in human development. They have an established role in regulating β cell development and function, with dysregulation resulting in diabetes. Numerous limitations have restricted the study of these modifications directly in pancreatic tissue. We utilize a cohort of human fetal pancreatic samples to determine […]

Introduction and Objective: Despite its systemic impact, MASLD is often overlooked in routine T2DM care. Our study evaluates whether glycemic status and the NFS are associated with the prevalence and severity of microvascular complications in hospitalized patients with T2DM.Methods: Our retrospective cross-sectional study analyzed data from 4,009 hospitalized patients with T2DM in Almaty, Kazakhstan (2017-2019). […]

Introduction and Objective: Recurrent insulin-induced hypoglycemia blunts the counterregulatory response (CRR) to hypoglycemia. Since antecedent hyperinsulinemia coincides with antecedent hypoglycemia, it is possible that recurrent insulin administration per se could contribute to the pathophysiology of a blunted CRR. To target insulin delivery to the central nervous system, this study tested the hypothesis that recurrent intranasal […]

Introduction and Objective: Physical activity (PA) is important in type 1 diabetes (T1D) management. However, PA poses challenges as it can cause unpredictable changes in blood glucose (BG) levels. Key reasons include insulin-glucose mismatch, nutrition, type of activity, and individual variability. The Clinical Sports and Activity Program (CSAP) at the Wendy Novak Diabetes Institute educates […]

Introduction and Objective: Type 1 diabetes (T1D) increases the risk of depression. Pregnancy can be a particularly stressful time for women with T1D, but little is known about pregnancy-related psychosocial health in this population. We report on the prevalence of depressive symptoms and diabetes distress measured by validated surveys among pregnant and postpartum women participating […]