Author: sugaradmin

Introduction and Objective: Novel once-weekly therapies targeting complementary pathways, such as basal insulin and GLP-1 RA, may simplify management and improve outcomes in type 2 diabetes (T2D). This study aimed to evaluate the short-term effects of icodec plus tirzepatide in a real-world setting.Methods: This retrospective observational study included 21 adults with long-standing T2D initiating icodec […]

Introduction and Objective: Tumor necrosis factor (TNF)-alpha signaling is associated with obesity and insulin resistance, although its role in beta-cell function has not been addressed. The TNFRSF1A gene encodes the tumor necrosis factor receptor 1 (TNFR1;p55), which is bound by the cytokine TNF-alpha. Signaling through this pathway activates the NF-κB pathway and overactive inflammatory pathway […]

Introduction and Objective: Patients with type 1 Diabetes (T1D) increasingly exhibit metabolic syndrome features, a phenotype termed “Double Diabetes.” We investigated the interaction of HbA1c and BMI with cardiovascular (CV) risk factors in a large cohort.Methods: This is a cross-sectional analysis of 1,266 persons living with T1D. CV risk was quantified by a composite score […]

Introduction and Objective: Incidence of diabetes in youth is expected to increase in the US and surveillance efforts have faced challenges. Using comprehensive electronic health record data from Kaiser Permanente Southern California (KPSC), we estimated diabetes incidence in youth 0-17 years from 2018-2024.Methods: Denominators included membership counts of youth <18 years on December 31 of […]

Introduction and Objective: We assessed the effect of CagriSema on eating control and behavior in adults with overweight/obesity.Methods: In REDEFINE 1 (NCT05567796), 3417 adults (67.6% female; mean: age, 47.0 years; body weight, 106.9 kg; BMI, 37.9 kg/m2) were randomized 21:3:3:7 to once-weekly CagriSema 2.4 mg/2.4 mg (n=2108), semaglutide 2.4 mg (n=302), cagrilintide 2.4 mg (n=302), […]

Introduction and Objective: The aim of this study was to analyze the effectiveness of a tubeless AID system on glucose metrics in patients with type 1 diabetes (T1D).Methods: We collected glucose data (TIR, TBR, TAR, CV GMI and GRI) from 94 T1D patients (age 37±13 years; M/F = 35/59; diabetes duration 19±13 years; HbA1c 7±1%; […]

Introduction and Objective: Sleep impacts diabetes health and mental and physical well-being, and young adulthood can bring new sleep situations (e.g., late nights, living with roommates). Sleep may also be impacted by T1D symptoms and treatment. While previous research links daytime social support to positive diabetes outcomes, less is known about nighttime support and strategies […]

Introduction and Objective: RDSY1801 is a novel GLP-1 peptide composed of a single mutation in Thr7→Pro and activates GLP-1R. This is the first-in human study of oral RDSY1801 capsules, designed to investigate its pharmacokinetics and safety in healthy adults.Methods: Total 54 healthy volunteers participated in the single escalation dose study. Participants were randomized into six […]

Introduction and Objective: Accurate, non-invasive body composition assessment is vital for evaluating anti-obesity therapies, yet conventional methods often lack resolution to distinguish beneficial fat loss from unintended lean mass reduction. To validate a high-resolution, multimodal imaging platform, we used semaglutide, a GLP-1 agonist with known effects on fat and muscle, as a positive control in […]