Author: sugaradmin

Introduction and Objective: The National Health Service (NHS) England hybrid closed-loop (HCL) pilot provided access to HCL for adults with type 1 diabetes (T1D), managed with an insulin pump and intermittently scanned continuous glucose monitoring, with a HbA1c ≥8.5%. We assessed the factors associated with improved diabetes-related distress (DRD) at follow up.Methods: Anonymized baseline and […]

Introduction and Objective: We evaluated the association between social isolation, loneliness, and stroke risk in individuals with diabetes (DM) (vs. euglycemia) and assessed sex differences in the association.Methods: We included participants with DM (N=40,684) (defined by self-reported DM diagnosis, DM medication, HbA1c>6.5%, ICD codes) and sex-, race-, age-, and center-matched euglycemic individuals (1:1) from the […]

Introduction and Objective: Open-source automated insulin delivery (OS-AID) has been shown to improve glycemic control in people with type 1 diabetes (PWT1D). We compare the effectiveness, safety, and fear of hypoglycemia (FOH) between OS-AID and commercial (C-AID) systems during Ramadan fasting.Methods: We recruited 114 PWT1D fasting during Ramadan 2024 using an AID system [OS-AID (n=7) […]

Introduction and Objective: To evaluate the impact of psychosocial factors, as assessed by the INSPIRE Questionnaire, and perceptions of technology efficacy (TES metrics) on glycemic outcomes and user acceptance of FCL systems in adults with type 1 diabetes.Methods: Data were analyzed from a cohort of 12 adults with T1D who participated in a 1-week at […]

Introduction and Objective: Intermittent fasting, including Ramadan fasting, increases the risk of hypoglycemia in people with type 1 diabetes (PWT1D). We examined the prevalence and predictors of fear of hypoglycemia (FOH) after Ramadan in PWT1D who attempted to fast.Methods: Fasting experience, glycemic control, and FOH were evaluated in 159 PWT1D who attempted to fast Ramadan […]

Introduction and Objective: Inflammation is associated with progression of diabetic retinopathy (DR). Inflammatory cytokines tumor necrosis factor alpha (TNFα), interleukin-1β (IL-1β), and interleukin-6 (IL-6) are elevated in DR and trigger retinal microvascular leakage. RMEC tight junction complexes include the transmembrane proteins occludin and ZO-1. Diabetic relevant stimuli cause changes in occludin and ZO-1 localization and […]

Introduction and Objective: Accurate glucose prediction is vital for effective glucose management during physical activity (PA) [1], as PA significantly impacts glucose dynamics. This study evaluates the integration of heart rate (HR) and step count per minute (SCPM) data into deep learning (DL)-based glucose prediction models.Methods: The T1DEXI dataset [2] was used (561 T1D adults […]

Introduction and Objective: The utility of lactate as an indicator of metabolic dysfunction during pregnancy is unknown. This study determined if blood lactate is related to established markers of metabolic dysfunction (insulin resistance, obesity, substrate oxidation) in pregnancy. Methods: Respiratory quotient (RQ) and blood was collected before and serially after a high-fat meal. Glucose and […]

Introduction and Objective: Insulin sensitivity factor (ISF) is often considered constant in Automated Insulin Delivery systems and other insulin therapies, but ISF varies with glycemia [1]. This study assesses the impact of glycemia (G) on ISF using real-life data.Methods: Data from 11,201 T1D adults using the DBLG1 System since March 2021 was used. G peaks […]

Introduction and Objective: In 4T Study 1, youth with new-onset T1D start CGM <30 days after diagnosis, receive weekly remote CGM data review by a CDCES, and dose changes via secure portal messaging. We describe the policy CDCES used to make dose adjustments and report the safety and effectiveness of CDCESs, making incremental dose changes […]