Share on PinterestNew research identified a 27% increased risk of metabolic syndrome among subjects experiencing early natural menopause. Nazar Rybak/Getty Images A study has found that early menopause is linked with a higher risk of metabolic syndrome. Early natural menopause was associated with a 27% higher relative risk of developing the condition. Experts say recognizing […]
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Share on PinterestNew research provides robust evidence of the wide range of antidepressant side effects. Iuliia Bondar/Getty Images A large new study found that the side effects of antidepressants vary significantly by drug. Some medications resulted in weight loss, while others resulted in weight gain. Heart rate and blood pressure also differed notably among medications. […]
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Share on PinterestRates of peanut and food allergies in young children have dropped significantly following changes to early introduction guidelines. Lindsey Rivera/Stocksy United Peanuts are one of the most common causes of potentially lethal food allergies. Evidence suggests that early introduction of certain foods can help prevent allergies. A new study confirms that these recommendations […]
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Share on PinterestExperts say California’s new affordable insulin program is a breakthrough for people with diabetes. Getty Images California has launched a program to manufacture and sell lower-cost insulin to people with diabetes. State officials say consumers will be able to purchase a five-pack of insulin pens for $55 in January 2026. The state has […]
Read MoreThe recent identification of liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous antagonist and inverse agonist of the growth hormone secretagogue receptor (GHSR) has revived interest in targeting the ghrelin-GHSR pathway for obesity treatment. Here, we assessed the preclinical efficacy of treatment with a long-acting LEAP2 (LA-LEAP2) analog for weight loss and explored its potential […]
Read MoreAn acute increase of lipids in the upper small intestine (USI) of rodents and humans triggers lipid-sensing pathways to reduce food intake. However, USI lipid sensing does not reduce feeding in high-fat (HF) fed conditions, and the underlying mechanism remains elusive. Here, we report that HF feeding in male rats impaired USI lipid infusion to […]
Read MoreIn type 1 diabetes (T1D), insulin (INS) deficiency results from immune-mediated destruction of β-cells. The majority of functional β-cell mass is typically lost within months to years of disease diagnosis, but the timing and nature of this loss, particularly in early disease stages, remain unclear. We developed a whole-slide scanned image analysis pipeline for semiautomated […]
Read MoreAn accurate genetic diagnosis of maturity-onset diabetes of the young (MODY) is critical for personalized treatment. To avoid misdiagnosis, only genes with strong evidence of causality must be tested. Heterozygous variants in NEUROD1, PDX1, APPL1, and WFS1 have been implicated in MODY, but strong genetic evidence supporting causality is lacking. We therefore assessed their existing […]
Read MoreDiabetes has a large medical and public health impact in American Indians. Studies have used genetic data to distinguish type 1 diabetes (T1D) and type 2 diabetes (T2D) and uncover biologic mechanisms underlying T2D clinical heterogeneity. We applied a T1D polygenic score (PS) to 3,084 American Indians (mean age 56 years, 58% women, 39% diabetes). […]
Read MoreDiabetic retinopathy (DR) is characterized by microvascular damage and increased vascular permeability in the retina. The investigation of visual outcomes in late-stage DR is limited by challenges of maintaining chronically hyperglycemic mice, and most reports are restricted to early-stage DR. In this study, we used carefully managed diabetic mice to longitudinally investigate associations between vascular […]
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