Author: sugaradmin

Introduction and Objective: This study evaluated the prevalence of food insecurity (FI) among adults with diabetes initiating continuous glucose monitoring (CGM) therapy compared to national averages and examined associations with gender, age, and glycemic outcomes.Methods: Fifty adults initiating CGM therapy were screened for FI using the USDA Six-Item Short Form. Individuals with an FI score […]

Introduction and Objective: A short-term study in obese T2D patients showed that the combination of dorzagliatin, a glucokinase activator (GKA) and sitagliptin improved glucose controls with increased GLP-1 secretion. This study aims to assess the impact of long-term administration of dorzagliatin and the combination of dorzagliatin/sitagliptin on glucose homeostasis in high-fat diet-induced obesity/diabetes (DIO) mice.Methods: […]

Introduction and Objective: CK-0045 is a novel long-acting IL-22 receptor agonist with great potential for treatment of patients with metabolic diseases based on preclinical data. Here we present the results of a randomized, double-blind, placebo-controlled, Phase 1 study investigating safety, tolerability, and pharmacokinetics of CK-0045 in healthy participants with and without obesity.Methods: A total of […]

Introduction and Objective: Few studies have explored the experiences of people newly diagnosed with type 2 diabetes (T2D). This study aimed to understand these experiences through in-depth interviews to identify unmet psychosocial needs.Methods: Thirty adults with T2D diagnosed within the past six to nine months were interviewed using a semi-structured guide to capture their experiences […]

Introduction and Objective: Teplizumab is the first therapeutic to demonstrate the ability to delay progression from stage 2 to stage 3 type 1 diabetes (T1D). In this extension of the TrialNet stage 2 teplizumab study (TN-10), we followed participants who received a course of teplizumab after developing stage 3 T1D.Methods: TN-10 Extension was a multicenter, […]

Introduction and Objective: The causes and management of diabetes are widely misunderstood. The prevailing narrative misrepresents diabetes as a self-inflicted condition, attributed to laziness, gluttony, and irresponsibility. While many health care professionals are supportive, evidence suggests biases exist in diabetes care. The purpose of this study was to examine if these biases develop early in […]

Introduction and Objective: Obesity and type 2 diabetes are associated with mitochondrial dysfunction and reduced plasticity of white adipose tissue (WAT), characterized by impaired adaptive responses to metabolic demands. miR-22 plays a key role in lipid metabolism dysregulation, and its inhibition has been shown to restore metabolic homeostasis in preclinical models. RES-010, a first-in-class antisense […]

Introduction and Objective: The aim was to analyze which glycemic parameters predict sleep quality and whether sleep quality predicts psychosocial well-being.Methods: People with type 1 and type 2 diabetes rated their sleep quality daily for 17 days (range: 0-10) on a ecological momentary assessment (EMA) app. CGM was used to calculate %<70 mg/dl (TBR), %>180 […]

Introduction and Objective: Delayed access to insulin (DAI) during pregnancy can have a major impact on effective diabetes management, posing risks to mother and infant. We sought to assess the frequency of DAI (≥ 7 days) in pregnant women and identify associated factors.Methods: Of 1262 pregnant women aged ≥18 with GDM or pre-existing T2DM who […]

Introduction and Objective: Behavioral Family Systems Therapy for Diabetes (BFST-D), a family-based pediatric psychosocial type 1 diabetes (T1D) intervention, improves glycemic levels and family conflict. A brief group-based version of bBFST-D has evidence of effectiveness. However, few families receive this care. Using evidence-based quality improvement (EBQI), the current study aimed to develop and tailor a […]