Author: sugaradmin

Introduction and Objective: Non-alcoholic steatohepatitis is a prevalent metabolic liver disease with limited therapeutic options. This study aimed to investigate the therapeutic potential of intestinal epithelial organoid (IEO)-derived exosomes in treating steatohepatitis.Methods: IEOs were generated from the small intestinal tissue of eight-week-old C57BL/6 mice, and exosomes were isolated from IEO culture supernatants. Human hepatoma HepG2 […]

Introduction and Objective: Evidence-based pediatric psychosocial type 1 diabetes (T1D) care improves child (glycemic levels, diabetes distress) and family (conflict) health outcomes. However, few intervention studies have included substantial proportions of African American or low income families of any race. This community-engaged study aimed to identify strategies to increase engagement of these families in T1D […]

Introduction and Objective: This study aims to determine the minimum weight loss required for diabetes prevention in the Korean population.Methods: The Korean Diabetes Prevention Study (KDPS), a prospective, multicenter, randomized controlled trial, enrolled prediabetic adults aged 30-70 with a body mass index ≥23 kg/m2 from 2016 to 2022. Participants were assigned to standard management, lifestyle […]

Introduction and Objective: Substance use (SU) and SU disorders (SUDs) adversely affect diabetes management and increase the risk of diagnosed diabetes (DM) complications. We estimated disparities in the prevalence of SU, SUDs, and SUD treatment among those with SUDs (SUDT) among US adults with DM by sociodemographic characteristics.Methods: We used 2021-2022 National Survey on Drug […]

Introduction and Objective: β cell dysfunction is the driving force of type 2 diabetes mellitus (T2DM) pathogenesis. SIRT7 is an NAD+-dependent lysine deacetylase with diverse functions in glucose metabolism. However, its role in islet remains uncharacterized. Here, we explored the functional role of SIRT7 in β cell physiology and pathophysiology.Methods: We generated Sirt7 β cell […]

Introduction and Objective: Reducing loneliness and lack of social and emotional support (LSES) among adults with diabetes (DM) can improve diabetes management and health outcomes. Considering the distinct pathophysiology and risk factor profile of each diabetes type, we explored the prevalence of loneliness and LSES among adults with type 1 or type 2 DM using […]

Introduction and Objective: Comprehensive telehealth improves control of refractory chronic diseases in integrated health systems, but has seldom been implemented in fee-for-service (FFS) systems. We examined the use of comprehensive telehealth for uncontrolled T2D and hypertension in a FFS environment.Methods: This randomized effectiveness-implementation trial compared two 12-month mobile monitoring-enabled telehealth interventions: 1) a self-management program; […]

Introduction and Objective: Autosomal dominant hypocalcemia type 1 (ADH1) is a hereditary disease caused by activating mutation of calcium – sensing receptor (CASR) gene, manifested as low parathyroid hormone (PTH) levels, hypocalcemia and hypercalciuria. Its clinical manifestations range from mild asymptomatic to severe hypocalcemia, which may be accompanied by epileptic seizures in severe cases. To […]

Introduction and Objective: The rising prevalence of obesity and metabolic disorders, such as type 2 diabetes, highlights the need for effective dietary strategies to improve health outcomes. The Mediterranean diet has been well studied and shown to reduce chronic disease risk through its beneficial effects on body composition and glucose metabolism. The Australian Guide to […]

Introduction and Objective: Youth with T1D and elevated HbA1c experience higher rates of short- and long-term complications. While individuals from some racial and ethnic groups are at greater risk of disparities in HbA1c due to systemic barriers and discrimination, less is known about the impact on family functioning amongst youth already experiencing elevated HbA1c. This […]