Author: sugaradmin

Introduction and Objective: Obesity has reached epidemic proportions globally, posing a critical public health crisis. To address this, HM15275, a novel long-acting GLP-1/GIP/Glucagon triple agonist was developed, demonstrating potent weight loss and glycemic control in prior preclinical studies. The present study further investigates the effects of HM15275 on body weight and body composition over an […]

Introduction and Objective: The significance of adipose tissue macrophages (ATMs) in regulating adipose tissue function is well-established. However, our investigation revealed a previously overlooked subpopulation of macrophages adhered to adipocytes, which we term adhesion-related macrophages (ARMs).Methods: We developed a method to isolate both ARMs and non-ARMs. Molecular and functional differences were analyzed, and Cav-1 knockout […]

Introduction and Objective: Glucagon-like Peptide-1 receptor agonists (GLP1s) are comparable to insulin for the treatment of T2D and promote weight loss. There are limited data to guide GLP1 use in severely uncontrolled T2D (A1C ≥10%).Methods: We conducted a retrospective cohort study of 1,518 adults with T2D who were ordered a GLP1 or basal insulin within […]

Introduction and Objective: Despite a higher prevalence of prediabetes, the reach of the National Diabetes Prevention Program (DPP) has been challenging in rural areas. This study examines the preliminary utility of different recruitment strategies to improve proportion and representativeness (i.e., reach) of rural participants that enroll in the National DPP.Methods: Two Cooperative Extension sites in […]

Introduction and Objective: GLP-1 receptor agonists (GLP-1 RAs) are recognized for glycemic and metabolic benefits in type 2 diabetes and obesity. Emerging evidence suggests neuroprotective effects via GLP-1 receptor expression in key brain regions. This study evaluated whether GLP-1 RA therapy is associated with measurable changes in cognitive function via MMSE.Methods: This retrospective cohort study […]

Introduction and Objective: Diabetic Ketoacidosis (DKA) prevention protocols are underused and difficult to understand by patients. We aimed to co-create with people living with T1D, caregivers, and healthcare professionals a core DKA education infographic.Methods: Focus groups were recruited through purposive sampling. In a user-centered design process involving oversight by a User Advisory Panel, participants were […]

Introduction and Objective: Certain cardiovascular outcome trials (CVOTs) indicated that GLP-1RAs may offer a potential cardiovascular protection effect, but the current results are inconsistent. GLP-1RAs have been shown to reduce hsCRP, despite the unclear relationship between hsCRP and cardiovascular risk. This meta-analysis evaluates whether the changes in hsCRP influence the 3-point major adverse cardiovascular events […]

Introduction and Objective: While glucagon-like peptide 1 (GLP-1) therapies are effective treatments for metabolic disease, poor adherence linked to perceived treatment complexity and access remains a problem. We are developing a needle-free, shelf-stable, self-applied, microarray patch (MIMIXTM MAP) as a new mode of delivery to address these barriers. Here, we compare the bioavailability of MIMIX […]

Introduction and Objective: This post hoc analysis assessed the efficacy and hypoglycemia outcomes with once-weekly insulin icodec (icodec) vs once-daily (OD) basal insulin comparators in insulin-naive (ONWARDS 1, 3, 5) and insulin-experienced (ONWARDS 2, 4) adults with T2D by baseline A1C.Methods: Treatment outcomes were analyzed, by trial, across baseline A1C subgroups (≤8%, >8-≤9%, >9%).Results: Overall, […]

Introduction and Objective: CGM systems may support glucose control in patients in cardiac intensive care unit (CICU). We aimed to assess the accuracy, feasibility and tolerability of Dexcom One+ against standard blood glucose measurements.Methods: From September to December 2024, we included patients with known diabetes or hyperglycemia at admission >140 mg/dl hospitalized in the CICU […]