Author: sugaradmin

Introduction and Objective: The 52-week QWINT-2 phase 3 trial demonstrated non-inferiority in HbA1c change from baseline with low, comparable hypoglycemia rates for efsitora, a novel once-weekly basal insulin (N=466), vs degludec (N=462) in insulin-naïve adults with type 2 diabetes (T2D). Here, we report the patient-reported outcomes.Methods: The TRIM-D assessed 5 domains: treatment burden, daily life, […]

Introduction and Objective: Dapiglutide is a first-in-class GLP-1R/GLP-2R agonist in development for weight management designed to address low-grade inflammation and obesity-associated co-morbidities. Safety, tolerability, pharmacokinetics and pharmacodynamics of once-weekly s.c. dapiglutide were investigated in a phase 1b trial.Methods: In a double-blind, placebo-controlled trial, 54 healthy participants with BMI 27-39.9 kg/m2 (85% male, median age: 46 […]

Introduction and Objective: The 78-week QWINT-3 trial assessed once-weekly efsitora (n=655) vs once-daily degludec (n=331) in adults with T2D currently on basal insulin. Here, we report the patient reported outcomes (PRO) findings at week 26 (primary timepoint).Methods: TRIM-D assessed 5 domains at baseline and week 26: treatment burden, daily life, diabetes management, compliance and psychological […]

Introduction and Objective: The National Diabetes Prevention Program (NDPP) can reduce risk of type 2 diabetes (T2D), yet many people face barriers. Alternative diets to the NDPP low fat diet, such as a very low carbohydrate diet (VLCD), may improve engagement and outcomes. Thus, we are conducting a 12-month randomized controlled comparative effectiveness trial of […]

Introduction and Objective: Youth receiving BFST for diabetes experienced improved diabetes self-management, parent-adolescent communication, and HbA1c. The BFST Skills Inventory (BFST-SI) was developed to assess intervention fidelity and family skills. While this measure has been used in numerous intervention studies for youth with diabetes, it has yet to be validated. This study aimed to examine […]

Introduction and Objective: No specific legislation in the United States and various EU Member States explicitly recognizes ownership rights of medical data generated from wearable diabetes devices. Clear medical data ownership laws are needed to define the rights of patients as well as those who wish to use patient-generated data.Methods: We performed a PubMed literature […]

Introduction and Objective: Insufficient physical activity (PA) is a significant risk factor of the development of diabetes and negatively impacts diabetes management and overall health. PA is derived from various sources, including work-related, transportation, and recreational activities. This study investigates sociodemographic factors associated with these different PA sources and diabetes status.Methods: Self-reported PA data from […]

Introduction and Objective: To characterize people with T1D (pwT1D) using CGM and the proportion meeting glycemic targets (time in range [TIR], time above and below range, coefficient of variation [CV], and glucose management indicator [GMI]) over time.Methods: A retrospective observational study was conducted using TriNetX’s Electronic Health Record (EHR) and linking it to Glooko’s CGM […]

Introduction and Objective: The prevalence of diabetes distress in adults with type 2 diabetes (T2D) is high yet interventions aiming to prevent diabetes distress are lacking. Our study aimed to evaluate the feasibility and acceptability of an intervention to facilitate conversations about diabetes distress in group-based patient education.Methods: Four visual dialogue tools aiming to increase […]

Introduction and Objective: Diabetic retinopathy (DR) is associated with high cardiometabolic risk and early multisystem disease. We aim to see if holistic assessment of patients with DR can identify treatable disease. Using multi-organ imaging, we evaluated the prevalence of disease (pancreas, liver, heart, kidney) in individuals with DR, and no known prior cardiovascular disease.Methods: We […]