Month: October 2026

Hyperglycemia in prediabetes is accompanied by increased amino acid (AA) concentrations and impaired suppression of glucagon secretion by glucose. It is unknown whether an abnormal response to AA contributes or hepatic steatosis exacerbates α-cell dysfunction. Therefore, lean participants and participants with obesity (with and without hepatic steatosis) were studied on two occasions in random order […]

While insulin activates the sympathetic nervous system in experimental settings, whether therapeutic insulin administration is associated with cardiac sympathetic predominance under free-living conditions remains unclear. This prospective observational study investigated the association between insulin dosing and cardiac autonomic balance in adults with type 1 diabetes managed exclusively with insulin therapy. Participants underwent continuous heart rate […]

Abnormal iron metabolism and ferroptosis contribute to diabetic cardiomyopathy (DCM); however, the regulatory mechanisms remain unclear. Inulin improves systemic metabolism and cardiac function, but whether it alleviates myocardial ferroptosis and DCM is unknown. Using two distinct type 2 diabetes (T2D) mouse models—the high-fat diet combined with streptozotocin–induced T2D model and the db/db mouse model—in combination […]

Protein posttranslational modifications, including lactylation, have been intimately associated with myocardial energy metabolism. In this study, we investigated the role of Cryab in diabetic cardiomyopathy (DbCM) and its lysine lactylation (Kla). A spontaneous DbCM mouse model in db/db mice and a high-fat diet combined with i.p. streptozotocin injection mouse model were used. Primary cardiomyocytes were […]

For decades, central regulation of body weight has been framed around peptide ligands, neuronal populations, and circuits. Primary cilia add an essential spatial dimension. A neuron may express the right receptor and sit in the right circuit yet still fail to interpret metabolic cues if the relevant signaling machinery is not assembled at the correct […]

“The first time you look into a microscope is pretty amazing. Seeing that we are made of tiny, tiny bits that all work together as one organism,” Bruce Verchere says. He had initially been more interested in physics, but an undergraduate biology course at the University of British Columbia (UBC)—Vancouver piqued his interest in physiology. […]

In a recent issue of Diabetes, Liu et al. (1) report associations between corneal nerve abnormalities and diabetic retinopathy (DR) severity in individuals with type 2 diabetes. The scale of the cohort, breadth of corneal phenotyping, and inclusion of inflammatory tear biomarker analyses are notable strengths. However, several methodological and conceptual concerns materially limit interpretation of […]

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