Diabetic retinopathy (DR) remains a leading cause of blindness, characterized by progressive neurovascular dysfunction. While the enzyme 12/15-lipoxygenase (12/15-LO) and its metabolites are upregulated in DR, their interactions with epigenetic regulators, such as miRNAs, are poorly understood. This study investigates the role of 12/15-LO in miRNA dysregulation and its functional consequences in a type 1 diabetic […]
Read MoreMonth: August 2026
FcRn Upregulation Exacerbates Podocyte Injury via Insulin Resistance–Induced Autophagy Disorder in Diabetic Kidney Disease
Diabetic kidney disease (DKD) remains the leading cause of end-stage renal disease worldwide, despite therapeutic advances. Podocyte injury constitutes a critical pathogenic process in DKD. This study elucidated the role of the neonatal Fc receptor (FcRn) in DKD-associated podocyte injury. In DKD, glomerular FcRn expression was markedly elevated and inversely correlated with podocin levels. In […]
Read MoreIssues and Events
Issues and Events Source link
Read MoreReopening the Energy Deficit: Beige Adipocytes in Weight Loss Therapy
German Center for Diabetes Research Source link
Read MoreDiabetes Spotlight: John Ussher, PhD—Unlocking the Secret Cardiovascular Benefits of GLP-1–Based Medicines
“They say first impressions are important,” John Ussher says. He remembers giving a research presentation during his undergraduate years at the University of Alberta, his first time speaking publicly in front of a room full of professors. “There was no laser pointer,” he says. “I had a wooden stick, I was nervous, and I was […]
Read More
FDA Upgrades Publix Recall of Frozen Blueberries to Class I
Share on PinterestThe FDA upgraded a recall on organic frozen blueberries and mixed berries from Publix to Class I. Flavia Morlachetti · Moment/Getty The Food and Drug Administration (FDA) upgraded the recall of frozen GreenWise Organic Whole Blueberries and Whole Mixed Berries from Publix to Class I. A Class I recall indicates the highest level […]
Read More
mRNA Vaccine May Help Prevent Recurrence and Spread
Share on PinterestA personalized mRNA melanoma vaccine developed by Moderna and Merck shows promise in reducing recurrence and spread. Iparraguirre Recio · Moment/Getty A late-stage trial found that a personalized mRNA therapy for melanoma outperformed Keytruda alone on two important measures of treatment success. The experimental treatment is tailored to the unique mutations in each […]
Read More
Just 1 Sugary Drink a Day More Than Doubles Risk of Stomach Cancer
Share on PinterestDrinking at least one sugary beverage a day could more than double your risk for stomach cancer. Milky Way/Moment/Getty Images A new study reports that drinking at least one sugar-sweetened beverage a day could more than double a person’s risk of stomach cancer. Researchers say that artificially sweetened beverages were not linked to […]
Read MoreGlucagon-like peptide-1 receptor agonists for primary cardiovascular disease prevention in type 2 diabetes, a systematic review
We aimed to estimate the cardiovascular (CV) benefit of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in patients with type 2 diabetes (T2D) without a history of CV disease (CVD) (primary CVD prevention). We searched MEDLINE and the Cochrane Central Register of Controlled Trials for randomized controlled trials (RCTs) and Epistemonikos for systematic reviews (up to […]
Read More
Childhood Vaccine Exemptions Hit Record High as Measles Cases Soar
Share on PinterestChildhood vaccine exemptions for medical or religious reasons have reached a record high. SDI Productions/E+/Getty Images A CDC report shows that MMR vaccination coverage among U.S. kindergartners fell from 92.5% in 2024–25 to 92.4% from 2025–26, well below the 95% associated with herd immunity against infectious diseases like measles. Medical or religious exemptions […]
Read More