Share on PinterestDolly Parton speaks onstage during Kicking Off CMA Fest: A Special Conversation With Dolly Parton Hosted By Rachel Smith at Music City Center on June 06, 2024, in Nashville, TN. Photo by Terry Wyatt/WireImage/Getty Images Country music legend Dolly Parton has died at age 80, her family announced on August 25. The singer-songwriter’s […]
Read More
Share on PinterestRecent research shows that entering menopause early may lead to faster cognitive decline and an earlier onset of Alzheimer’s disease. Kathrin Ziegler · DigitalVision/Getty Earlier menopause may be associated with faster cognitive decline and less favorable brain health later in life. These associations may persist for decades after the menopause transition. Earlier menopause […]
Read More
Weight maintenance is a challenging topic for both clinicians and patients. In this special episode, Neil Skolnik is joined by Jamie Almondoz, MD, who discusses the toxic narratives that have historically been part of the weight loss conversation, and the latest strategies for maintaining a healthy weight after the initial loss. This special episode is […]
Read More
Share on PinterestResults from two clinical trials show that a common rheumatoid arthritis drug, upadacitinib, supported hair regrowth in alopecia. Viktoriya Skorikova/Moment/Getty Images Researchers report that the drug upadacitinib, used to treat rheumatoid arthritis, effectively treated the hair loss condition alopecia areata in two clinical trials. The medication, sold under the brand name Rinvoq, is […]
Read More
As confusion and misunderstanding about perimenopause persist, learn how to recognize and manage symptoms of this life transition. Share on PinterestNot everyone experiences perimenopause in the same way. The timing, severity, and symptomology may differ greatly from one person to the next. Olga Pankova/Moment/Getty Images Perimenopause has only recently entered the cultural conversation despite being […]
Read More
Share on PinterestYoung men are “T-maxxing” their testosterone levels on social media to optimize their bodies and mood. aire images/Moment/Getty Images “Testosterone-maxxing” or “T-maxxing” is a social media trend that promotes testosterone for improved strength, appearance, and confidence in young men. While medically appropriate in some cases, boosting testosterone with unprescribed hormones can suppress natural […]
Read MoreOptimal function of beige adipocytes is essential for energy balance and metabolic homeostasis. We previously identified that cholinergic receptor nicotinic α2 subunit (CHRNA2) mediates a beige fat selective signaling in mice and humans. Here, we investigate the molecular composition of CHRNA2-containing nicotinic acetylcholine receptors (nAChRs) in beige adipocytes and its impact on whole-body metabolism. Expression […]
Read MoreCentral administration of fibroblast growth factor-19 (FGF19) has been shown to reduce body weight in obese mice, but the underlying mechanisms remain largely unknown. Here, we show that ribosomal S6 kinase 4 (Rsk4) is required for FGF19 to counteract obesity. Rsk4 is predominantly expressed in hypothalamic neurons. While loss of Rsk4 has negligible effects on […]
Read MoreThioredoxin-interacting protein (TXNIP) is regarded as a potential therapeutic target in type 2 diabetes. Hyperglycemia can upregulate the expression of TXNIP in various cell types, thereby inducing oxidative stress. However, the regulatory mechanisms by which this protein modulates vascular function in the aorta remain incompletely elucidated. This study aimed to investigate the response of TXNIP […]
Read MoreThe progressive decline of functional β-cell mass is a hallmark of type 2 diabetes (T2D), yet no current therapies effectively halt this process. While chronic inflammation and metabolic stress contribute to β-cell dysfunction, the key signals integrating these pathways remain elusive. Circulating adenosine deaminase (ADA) elevation in people with diabetes is often viewed as a […]
Read More