Month: June 2026

Introduction and Objective: The AKI-to-CKD transition lacks effective therapies. Cathepsin L (CTSL), a protease involved in renal fibrosis, is a potential target. This study determined whether CTSL inhibition alleviates progression in a murine IR injury model.Methods: 8-week-old male C57BL/6J mice received a CTSL inhibitor (998, 10mg/kg/day) or vehicle by oral gavage, starting 2 days before […]

Introduction and Objective: Disparities in diabetes technology use are now well described in youth with type 1 diabetes, but little is known about the role of medical mistrust and racism in healthcare as it relates to technology use.Methods: Baseline surveys from a larger intervention study with 51 caregivers of Non-Hispanic Black youth with type 1 […]

Introduction and Objective: Adult-onset autoimmune diabetes (AD), driven by immune-mediated β-cell destruction, leads to early failure of oral antidiabetic agents and rapid insulin requirement. Fourlanos et al. (2006) proposed a five-item clinical score (age <50 years, BMI<25 kg/m², personal history of autoimmune disease, family history of autoimmune disease, and acute hyperglycemic symptoms at diagnosis) to […]

Introduction and Objective: Individuals with PDN experience substantial reductions in quality of life due to both pain and loss of sensory function. A multicenter RCT evaluated the effectiveness of 10kHz SCS plus conventional medical management (CMM) versus CMM alone for improving pain and sensory function in people with PDN.Methods: Eligible PDN participants with lower-limb pain […]

Introduction and Objective: This secondary analysis of the GO MOMs cohort evaluated associations of first trimester maternal BMI, CGM, OGTT, HbA1c and metabolic measures with newborn adiposity.Methods: At 9 US centers gravidas with singletons and no pre-existing diabetes underwent 75g OGTT, HbA1c, CGM and fasting lipid measures (free fatty acids-FFA; triglycerides-TG) at 10-14 weeks’ gestation. […]

Introduction and Objective: Diabetic vasculopathy is a major complication of type 2 diabetes (T2DM), and endothelial senescence is a key driver of endothelial dysfunction and impaired angiogenesis. We tested whether ANGPTL8 promotes endothelial senescence in T2DM and explored the underlying mechanism.Methods: HUVECs were treated with recombinant ANGPTL8. qPCR assessed P21, P53, senescence-associated secretory phenotype genes […]

Introduction and Objective: In NOD mice, impaired T cell development and negative selection are implicated in disease development. However, in T1D patients, it remains unknown whether abnormalities in thymic selection contribute to disease development. Our knowledge of human T Cell Receptor (TCR) repertoire formation is limited by lack of access to human thymi. Thus, humanized […]

Introduction and Objective: E-cigarette use has become highly popular among youth and adults. This study examined how electronic cigarette exposure alters the serum proteome in mice and explored the role of nicotine-induced lipolysis in these changes. We have observed impaired cardiac function and increased oxidative stress following e-cigarette exposure. We hypothesized that lipolysis triggers systemic […]

Introduction and Objective: While closed-loop (CL) technology has transformed outpatient diabetes care, evidence in acute settings is limited. This systematic review and meta-analysis (PROSPERO: CRD420251133486) evaluated the safety, efficacy, and implementation of closed-loop technology in acute care.Methods: Eligible studies included adults managed with CL in acute care reporting glycaemic, safety, and implementation outcomes compared with […]

Introduction and Objective: Diabetes Mellitus is strongly associated with vascular complications. While molecular mechanisms of hyperglycemia-induced vascular dysfunction have been extensively studied, the organization of mechanical forces within endothelial monolayers under sustained hyperglycemia remains poorly defined. We investigated whether prolonged hyperglycemia alters endothelial force organization over time.Methods: Human Umbilical Vein Endothelial Cells were cultured in […]