Month: June 2026

Introduction and Objective: Sleep impacts diabetes health and mental and physical well-being, and young adulthood can bring new sleep situations (e.g., late nights, living with roommates). Sleep may also be impacted by T1D symptoms and treatment. While previous research links daytime social support to positive diabetes outcomes, less is known about nighttime support and strategies […]

Introduction and Objective: RDSY1801 is a novel GLP-1 peptide composed of a single mutation in Thr7→Pro and activates GLP-1R. This is the first-in human study of oral RDSY1801 capsules, designed to investigate its pharmacokinetics and safety in healthy adults.Methods: Total 54 healthy volunteers participated in the single escalation dose study. Participants were randomized into six […]

Introduction and Objective: Accurate, non-invasive body composition assessment is vital for evaluating anti-obesity therapies, yet conventional methods often lack resolution to distinguish beneficial fat loss from unintended lean mass reduction. To validate a high-resolution, multimodal imaging platform, we used semaglutide, a GLP-1 agonist with known effects on fat and muscle, as a positive control in […]

Introduction and Objective: Offloading is a cornerstone of diabetic foot ulcer management, yet uncertainty remains regarding the comparative effectiveness of available offloading modalities. The objective of this study was to compare clinical outcomes associated with offloading strategies for diabetic foot ulcers.Methods: We performed a meta-analysis of studies evaluating offloading modalities for diabetic foot ulcers. Included […]

Introduction and Objective: National CEDER offers free services to researchers and community groups on community-engaged type 2 diabetes (T2D) programming and research. We assess client satisfaction with CEDER services and early indicators of change of capacity following the first year of services (9/2024-8/2025).Methods: Clients received REDCap survey links via email. Post-service surveys were sent immediately […]

Introduction and Objective: Protein lactylation is implicated in MASLD, yet its functional role remains poorly defined. This study investigated the mechanism through which AARS2 regulates SOD2 lactylation to drive MASLD progression.Methods: This study integrated multi-omics data from clinical and preclinical MASLD models to systematically assess AARS2 expression. Lactyl-proteomics identified SOD2 as a key target. Direct […]

Introduction and Objective: Social needs (SNs), such as food insecurity and unstable housing, heighten risk for type 2 diabetes (T2D) and limit engagement in prevention efforts. Latino communities experience disproportionately high rates of both SNs and T2D. Although SNs influence diabetes risk and prevention, little is known about how organizations delivering T2D prevention programs address […]

Introduction and Objective: The impact of glycemic variability (GV) on muscle mass in Type 2 diabetes mellitus (T2DM) remains unclear under the updated Asian Working Group for Sarcopenia (AWGS) 2025 criteria. We investigated the association between continuous glucose monitoring (CGM)-derived GV and low skeletal muscle mass (LSMM).Methods: This cross-sectional study included 614 hospitalized T2DM patients […]

Introduction and Objective: KAT8 (lysine acetyltransferase 8), also known as MOF or MYST1, acetylates diverse protein substrates to regulate multiple cellular processes. Although KAT8 is expressed in adipocytes and adipose tissue, its function in adipocytes is unknown. We previously generated a mouse model with adiponectin-expressing cell-specific deletion of KAT8 (KAT8AKO) and found that these mice […]