Month: June 2026

Introduction and Objective: GLP-1 receptor activation and amylin receptor activation are two complementary mechanisms of action for obesity treatments. Combination therapy of long-acting peptides semaglutide and cagrilintide have demonstrated enhanced efficacy over single agents for obesity treatment in clinical trials. Small molecules offer potential advantages over peptides, including scalability, room temperature shipping and storage, and […]

Introduction and Objective: To explore whether short-term intensive glucose control can minimize the escalation of treatment in poorly controlled type 2 diabetes.Methods: Patients with poorly controlled type 2 diabetes despite receiving two or more hypoglycemic agents were randomly assigned to three intensive glucose control groups, with a 36-week core period followed by a 24-week extension. […]

Introduction and Objective: Patients with T2D can be clustered into distinct etiologic subgroups, but it is not clear if the same is true for those with prediabetes (preDM). As metabolites mark the onset of T2D prior to clinical thresholds, we clustered individuals with preDM by preDM-related metabolites and examined subgroups for long-term T2D risk.Methods: Data […]

Introduction and Objective: T1D population health requires synthesizing multiple data points. GRI summarizes severity-weighted hypo/hyperglycemia into zone categories. We assessed whether GRI can be used to characterize a pediatric cohort in relation to CGM targets.Methods: We analyzed up to 24 months of CGM data in 225 children with T1D and calculated GRI in consecutive 14-day […]

Introduction and Objective: All-cause mortality has been on the decline among people with type 1 diabetes (T1D). Despite this trend, excess mortality remains high among people with T1D compared to those without T1D. We examined the all-cause and cause-specific mortality in a contemporary T1D cohort and explored factors that influenced mortality.Methods: Participants in the Coronary […]

Introduction and Objective: Annual eye examinations for diabetes (EEDs) are essential for early detection of diabetic retinopathy, yet adherence remains suboptimal, particularly in rural communities where access to eye care is limited. Autonomous AI systems offer a scalable approach to expand patient access at the point of care. We evaluated the real-world impact of LumineticsCore™, […]

Introduction and Objective: Rapid postprandial glucose rises during pregnancy may adversely affect offspring health, while practical dietary advice for gestational diabetes remains limited. In type 2 diabetes, premeal whey protein (WP) reduces postprandial blood glucose. We investigated whether preprandial WP attenuates glucose excursions after carbohydrate intake in pregnant women and explored underlying mechanisms.Methods: In this […]

Introduction and Objective: PVHMC4R and PBNMC4R neurons are central to the regulation of energy intake and glucose metabolism, yet the neurocircuit mechanisms underlying glycemic control at these neural nodes remain unclear. Here, we investigated whether a PVHMC4R → PBNMC4R neurocircuit contributes to glucoregulation using an intersectional viral mapping approach.Methods: To anatomically define this pathway, we […]

Introduction and Objective: Lifestyle-related circadian disruption, including night-shift work, increases susceptibility to obesity and type 2 diabetes. However, the long-term effects of maternal circadian misalignment during pregnancy on metabolic health of adult offspring remain unclear. We investigated whether gestational circadian disruption, modeled using a short-day (SD) light cycle, programs offspring for metabolic dysfunction.Methods: Pregnant C57BL/6J […]

Introduction and Objective: Reversion to normoglycemia is increasingly recognized as a key goal in pre-diabetes management. Weight loss is a vital strategy to facilitate prediabetes reversion. This study assessed the association of weight change patterns with prediabetes reversion.Methods: Data were from the China Health and Retirement Longitudinal Study Waves 1-3 (2011, 2013, and 2015). Participants […]