Month: June 2026

Introduction and Objective: Hypercortisolism is present in almost 1 in 4 patients with difficult-to-control type 2 diabetes (T2D) per the CATALYST study, yet often goes undetected as current diagnostics rely on single-timepoint assessments. These patients undergo escalation of medication for glycemic control without assessing underlying metabolic contributors. Continuous cortisol monitoring (CCM), analogous to continuous glucose […]

Introduction and Objective: While high-dose metformin use often signals advanced disease, the clinical relevance of dose-associated proteomic profile remains unclear. We aimed to identify a dose-dependent proteomic profile and associations with clinical traits and cardiometabolic events.Methods: In a discovery cohort of 1,246 Koreans with type 2 diabetes and eGFR >30 mL/min/1.73 m², we analyzed 5,416 […]

Introduction and Objective: Obesity is a major risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), yet it is metabolically heterogeneous. The impact of distinct metabolic states on MASLD risk across varying degrees of obesity remains unclear. We aimed to evaluate the associations between metabolic obesity phenotypes and liver fibrosis in MASLD.Methods: Two cross-sectional cohorts […]

Introduction and Objective: Negative comments on body image and visible weight loss from friends, family, and peers may influence treatment discontinuation. This study evaluated societal influences reported treatment discontinuation with GLP along with weight regain.Methods: This observational study included adults on GLP-1-based therapy for weight loss with a minimum follow-up of 1 year. Weight loss […]

Introduction and Objective: Glycemic fluctuations across the menstrual cycle have been reported in women with type 1 diabetes (T1D), yet evidence in Asian populations remains limited. This study aimed to explore phase-related differences in glucose profiles across the menstrual cycle in Chinese women with T1D using continuous glucose monitoring (CGM), with an additional exploratory case […]

Introduction and Objective: Health inequities continue to drive disparities in diabetes outcomes across the United States. To help identify barriers to facilitators of health equity improvement, the T1D Exchange QI Collaborative conducted an assessment of member centers.Methods: The annual T1DX-QI survey was administered via Qualtrics from August to October 2025 to collect data from 2023. […]

Introduction and Objective: Gastrointestinal tolerability is a key consideration for weight loss therapies targeting appetite-regulating pathways. Conditioned taste avoidance (CTA) in rodents is a widely used preclinical model to evaluate the potential of compounds to produce nausea and gastrointestinal discomfort. We compared food intake inhibition and CTA responses induced by a small molecule amylin receptor […]

Introduction and Objective: There are more than 101 million individuals living with diabetes in India.Meeting treatment goals for HbA1c, Blood pressure and Cholesterol(ABC) can help prevent diabetes complications.We assessed diabetes awareness, management gaps and attainment of ABC goals among rural South Indian with self-reported diabetes.Methods: The Telemedicine pRoject for screENing Diabetes and its complications in […]

Introduction and Objective: GLP-1 receptor activation and amylin receptor activation are two complementary mechanisms of action for obesity treatments. Combination therapy of long-acting peptides semaglutide and cagrilintide have demonstrated enhanced efficacy over single agents for obesity treatment in clinical trials. Small molecules offer potential advantages over peptides, including scalability, room temperature shipping and storage, and […]