Month: June 2026

Introduction and Objective: Use of the oral glycemic agent metformin (Met) in pregnancy has expanded beyond treatment of maternal diabetes, but effects on offspring metabolic health are understudied. Met is not metabolized by the maternal liver and is transported across the placenta, and in humans is associated with small for gestational age, increased postnatal catch-up […]

Introduction and Objective: Access to primary care and social determinants of health (SDOH) both impact diabetes care. We aimed to determine whether primary care (assessed as primary care physician [PCP] supply) modifies the association between SDOH and measures of diabetes care among Medicare beneficiaries.Methods: We used 2022 county data on PCP supply from the Area […]

Introduction and Objective: Ph3 studies have compared iGlarLixi vs individual components (LixiLan-O-AP, LixiLan-L-CN) or IDegAsp (SoliD) in Asian PwT2D. This pooled analysis investigated the effect of iGlarLixi on PPG and SMPG derived time in range (dTIR).Methods: Changes in SMPG profile were analyzed in the pooled iGlarLixi vs control arms of LixiLan-O-AP, LixiLan-L-CN and SoliD.Results: Baseline […]

Introduction and Objective: Despite substantial metabolic benefit, islet transplantation (ITx) shows variable graft durability, with ~30% of recipients not sustaining function over time. We used mixed effects regression within a causal directed acyclic graph (DAG) framework to describe baseline determinants of 1 year graft function.Methods: We evaluated data from 415 ITx recipients from the Collaborative […]

Introduction and Objective: Up to 30% of youth with type 1 diabetes (T1D) report elevated depressive symptoms, which negatively impact T1D management. Behavioral health interventions exist to improve mood and promote treatment engagement, but their high cost and long duration are implementation barriers. Further, <25% of youth with T1D referred for mental health services attend […]

Introduction and Objective: Patients with diabetes and intellectual, developmental, and physical disabilities (IDPD) often have worse glycemic control and greater complications but may be overlooked when prescribing diabetes technology. This project aimed to increase insulin technology prescriptions at an academic center by 15% in patients with diabetes and IDPD over one year using a physician […]

Introduction and Objective: Adipose tissue insulin resistance(IR) is related with metabolic disorders. However, evidence regarding sex differences in adipose IR remains limited. This study aimed to identify factors associated with adipose IR and to examine sex differences and their potential modifiers.Methods: This cross-sectional study included 9,935 adults undergoing routine physical examinations. Adipose IR index(Adipo-IR) was […]

Introduction and Objective: Adults with T2D not treated with insulin face distinct and ongoing self-management challenges. This qualitative study explored how CGM versus routine care (RC, without CGM) impacts psychological, behavioral, and emotional outcomes in this population.Methods: Semi-structured interviews were conducted virtually with a randomly selected subset of participants from the CONNECT randomized trial at […]

Introduction and Objective: In type 2 diabetes mellitus (T2DM) with atherosclerosis, high-density lipoprotein cholesterol (HDL-C) levels may appear normal, but may exhibit reduced functionality. ATP-binding cassette transporters play a crucial role in HDL functionality, but there are only a few clinical studies. We evaluated the levels of ABC transporters (ABCA1 and ABCG1) in T2DM compared […]

Introduction and Objective: A real-world assessment of the 1-year implantable Eversense 365 CGM System was conducted in adults with diabetes using open-loop insulin regimens.Methods: Anonymized sensor glucose (SG) data from the Eversense Data Management System (DMS) for the first 8277 sensors in the US were used to compare glucometrics from the 1st and 2nd 6-months […]