Month: June 2026

Introduction and Objective: In type 2 diabetes mellitus (T2DM) with atherosclerosis, high-density lipoprotein cholesterol (HDL-C) levels may appear normal, but may exhibit reduced functionality. ATP-binding cassette transporters play a crucial role in HDL functionality, but there are only a few clinical studies. We evaluated the levels of ABC transporters (ABCA1 and ABCG1) in T2DM compared […]

Introduction and Objective: A real-world assessment of the 1-year implantable Eversense 365 CGM System was conducted in adults with diabetes using open-loop insulin regimens.Methods: Anonymized sensor glucose (SG) data from the Eversense Data Management System (DMS) for the first 8277 sensors in the US were used to compare glucometrics from the 1st and 2nd 6-months […]

Introduction and Objective: Obesity associated with type 2 diabetes (T2DM) is known to cause white adipose tissue hyperplasia associated with oxidative stress. Stem/ progenitor cell therapy may provide a novel strategy for treating obesity- and diabetes-related complications. Our laboratory has shown success in using p53-silenced endothelial progenitor cells (EPCs) in disease models such as hyperglycemia-associated […]

Introduction and Objective: Gestational diabetes mellitus (GDM) increases the risk of early-onset prediabetes (<40 years). We hypothesized that biological pathways mediating the transition from pregnancy to early-onset prediabetes one year postpartum differ between women with prior GDM and those with normoglycemic (NG) pregnancies, using stratified longitudinal analyses with deep metabolic phenotyping.Methods: In the prospective, multicenter […]

Introduction and Objective: The natural history of type 2 diabetes (T2D) is characterized by a gradual decrease of insulin sensitivity and characteristically a steep decline of beta cell function short before diagnosis. However, recent data-driven sub-phenotyping has unveiled high-risk clusters of individuals with increased T2D risk, that differ profoundly in body fat distribution, insulin resistance […]

Introduction and Objective: Early vascular aging (EVA), based on vascular age gap (VAG), reflects excess vascular aging beyond chronological age, but its clinical relevance in type 1 diabetes (T1D) remains unclear. We aimed to characterize EVA based on carotid intima-media thickness (cIMT) and its associations with microvascular complications in adults with T1D.Methods: This cross-sectional study […]

Introduction and Objective: Hypercortisolism may reduce the efficacy of GLP-1 RAs or tirzepatide by disrupting the incretin system, impairing beta cell function, and inducing insulin resistance. The CATALYST trial studied the prevalence and medical treatment of hypercortisolism in people with difficult-to-treat T2D. This sub-analysis assessed treatment with mifepristone (mife) in participants on GLP-1 RAs or […]

Introduction and Objective: The neutrophil percentage-to-albumin ratio (NPAR) is a novel inflammatory marker linked to adverse cardiovascular outcomes. Its prognostic value in patients with lower extremity arteriosclerosis obliterans (LEASO) undergoing endovascular revascularization remains unclear. This study aimed to investigate the association between preprocedural NPAR and 1-year major adverse cardiovascular events (MACEs).Methods: A prospective cohort study […]

Introduction and Objective: Maintaining long-term weight loss is challenging, and the underlying mechanisms remain unclear due to substantial individual variability. We developed a Metabolomic Adaptation Response (MAR) Index that integrates early metabolomic changes to predict long-term weight loss and examined whether plasma microRNAs from key metabolic organs influence the MAR.Methods: Untargeted plasma metabolomics were performed […]

Introduction and Objective: Brown adipose tissue (BAT) presents a promising target to combat obesity and metabolic diseases. In humans, BAT mass and activity substantially decline with aging. However, the mechanisms underlying the age-related decline in BAT remain poorly understood. Due to their genetic and physiological similarities to humans, non-human primates (NHPs) provide a powerful model […]