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Read MoreMonth: March 2026
Distinct Host Responses to Enterovirus in Children With Islet Autoimmunity Provide a New Framework for the Role of Infections in Type 1 Diabetes
The high prevalence of enterovirus infections in the general population has made it difficult to consistently link these infections to type 1 diabetes or to identify specific associations with one or more serotypes. A temporal association between infections and diabetes onset, when known, is variable. Moreover, only a minority of those infected by enteroviruses develop […]
Read MoreDiabetes Spotlight: Dawn Belt Davis, MD, PhD—Strengthening β-Cell Functionality by Identifying Signaling Pathways
Through her parents, Dawn Davis was exposed to opposite ends of the medical field. Her mother worked and volunteered with community and health–related nonprofits. Her father was an engineer developing pacemakers and MRI machines. “I remember a prototype pacemaker at home, encased in liquid plastic,” Davis says, “and I was probably one of the first […]
Read MoreResponse to From Systemic B-Cell Targeting to Local Immune Engineering in Islet Transplantation
We appreciate the thoughtful commentary from Zhu et al. (1) regarding our study on B lymphocytes and regulatory T cells (Tregs) in type 1 diabetes and islet transplantation (2). We are pleased that they highlight our central observations in the NOD background, including the ability of B-cell deficiency to permit anti-CD45RB–mediated tolerance in the autoimmune type […]
Read MorePericytes Are Not Merely Accessory Cells in Pancreatic Islets
JDRF (Breakthrough T1D)3-PDF-2024-1503-A-NNIH RO1DK133483 and DK138471 Source link
Read MoreFrom Systemic B-Cell Targeting to Local Immune Engineering in Islet Transplantation
We read with great interest the recent study by Wilson et al. (1), which demonstrated that B lymphocytes impair regulatory T cell (Treg) development and function, thereby eroding islet tolerance in the NOD islet allograft model. Their findings show that B-cell deficiency enables durable graft acceptance following short course anti-CD45RB treatment, accompanied by Helios+ Treg expansion, improved […]
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Heart Health Benefits Fade After Stopping GLP-1 Drugs
Share on PinterestStopping GLP-1s can quickly reverse the cardiovascular benefits gained while taking them. Image Credit: the_burtons/Getty Images A recent study found that stopping GLP-1s, such as Ozempic or Wegovy, can reverse the cardiovascular benefits they provide. The findings show that stopping the medications for as little as 6 months raises the risk of heart […]
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New Guidelines Say Keep It Simple for Best Results
Share on PinterestNew resistance training recommendations emphasize consistency over complexity. Image Credit: Westend61/Getty Images You don’t need a perfect workout plan to benefit from strength training, according to new recommendations from the American College of Sports Medicine. A large new review finds that at-home workouts or body weight exercises can be just as effective as […]
Read MoreAfrican immigrants with type 2 diabetes present with three physiologic subtypes: implications for screening, diagnosis and treatment
Introduction As type 2 diabetes (T2D) prevalence increases in the USA and Africa, factors from both regions affect African immigrants. Objective T2D in African immigrants was characterized by examining: (a) insulin deficiency and insulin resistance; (b) phenotypic presentation; (c) sociodemographic factors. Methods In 633 African immigrants (male: 62%, age 39±11, (mean±SD), range 20–70 years), body […]
Read MoreAssociation of GLP-1 receptor agonists with intentional self-harm in patients with type 2 diabetes: a Sentinel Distributed Database study
Introduction The U.S. Food and Drug Administration (FDA) investigated the potential risk of suicidal ideation and behaviors for glucagon-like peptide 1 receptor agonists (GLP-1 RAs) on learning of post-marketing reports of suicidal ideation and behaviors in patients taking GLP-1 RAs. This study assessed a potential association with intentional self-harm comparing GLP-1 RAs to other antidiabetic […]
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