The high prevalence of enterovirus infections in the general population has made it difficult to consistently link these infections to type 1 diabetes or to identify specific associations with one or more serotypes. A temporal association between infections and diabetes onset, when known, is variable. Moreover, only a minority of those infected by enteroviruses develop type 1 diabetes. While a traditional proof of causality is lacking, the role of viruses in type 1 diabetes may not be easily explained by canonical mechanisms.
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