Month: July 2025

Introduction and Objective: Persistent proinsulin secretion and elevated proinsulin-to-C-peptide ratios have been reported in T1D. However, the potential of individual proinsulin proteoforms as biomarkers in T1D has not been evaluated due to the challenges associated with assay specificity. Herein, we present the first assessment of intact proinsulin, des-31,32 proinsulin, and des-64,65 proinsulin using a newly […]

Introduction and Objective: Alopecia is a potential adverse event of anti-obesity medications (AOMs). Rapid weight loss may result in deficiencies of key nutrients and act as a physiological stressor, potentially disrupting hair growth cycles and increasing hair shedding. This study aimed to evaluate the association between AOMs and risk of alopecia.Methods: PubMed, EMBASE, Cochrane Library, […]

Introduction and Objective: ASC30 is an oral GLP-1R biased small molecule agonist without β-arrestin recruitment, discovered and developed in-house at Ascletis. ASC30 has unique and differentiated properties that enable the administration of one small molecule as both a once-monthly subcutaneous injection and a once-daily oral tablet. The current study assessed safety, tolerability and pharmacokinetics of […]

Introduction and Objective: We measured the impact of online continuing medical education (CME) on knowledge and confidence of primary care physicians (PCPs) and diabetologists/endocrinologists (D/Es) on new data for using automated insulin delivery (AID) in people with T2D.Methods: The intervention comprised a 30-min online video-based discussion among 3 expert faculty with downloadable slides. Education effect […]

Introduction and Objective: Persons with type 1 diabetes (PWD) often experience nighttime fluctuations in blood glucose levels, which require active management. Those who sleep with a partner may receive instrumental support in diabetes management tasks. We examined whether partner nighttime awakenings that coincided with PWD awakenings predicted better blood glucose management following excursions.Methods: Eight emerging […]

Introduction and Objective: Ferroptosis of renal tubular epithelial cells (RTECs) is implicated in the pathogenesis of diabetic kidney disease (DKD). Bardoxolone methyl (BM), a synthetic triterpenoid with antioxidant and anti-inflammatory properties, has shown promise in clinical trials for preventing DKD-related renal decline but carries a risk of heart failure. Recent studies revealed that 2-deoxy-D-ribose (dRib) […]

Introduction and Objective: In a Phase III, randomized, placebo-controlled, multi-center study in which T2DM patients were treated with oral insulin for 26 weeks, the primary endpoint defined as a decrement of 0.6% HbA1c by end of treatment was not met. A post-hoc analysis aimed to identify subpopulations with substantial clinical responses to treatment.Methods: Explainable AI […]

Introduction and Objective: Diabetes and adipose research generate rich datasets whose accessibility and integration are often limited. To address this challenge, we created the Mammalian Adipose Tissue Knowledge Portal (MATKP; matkp.org), an open community portal for multi-species mammalian adipose biology. MATKP is accessible to diverse users and aggregates data for adipose tissues and cell types, […]

Introduction and Objective: HCL is the preferred insulin delivery method for people with T1D, however mealtime carbohydrate counting limits benefit. Use of AI to implement automated insulin delivery (AID) algorithms, able to avoid mealtime interactions, could alleviate burden and broaden use. We tested the latest UVA AID neural network-based system (AIDANET) in FCL in a […]

Introduction and Objective: There is a paucity of objectively measured physical activity (PA) data in underserved populations. We examined objectively measured and self-reported PA among Chinese immigrants with type 2 diabetes (T2D) in NYC.Methods: We analyzed baseline data from 60 participants. PA was measured by a wrist-worn ActiGraph GT9X accelerometer and the International Physical Activity […]