Month: July 2025

Introduction and Objective: The time of day that aerobic exercise is performed may alter the metabolic response leading to downstream effects on cardiometabolic health. This pilot study aimed to identify metabolites that are affected by time of day of exercise using metabolomics.Methods: Adults with overweight or obesity (BMI = 25-40 kg/m2) were randomly assigned to […]

Introduction and Objective: To identify risk factors and clinical outcomes for non-healing surgical wounds in patients admitted to the hospital for moderate and severe diabetic foot infections.Methods: This was a pooled analysis of patient level data from 2 RTCs. Moderate and severe diabetic foot infection (DFI) was based on criteria of the International Working Group […]

Introduction and Objective: Long-term impacts of gestational diabetes mellitus (GDM) on host metabolism are unknown. We aimed to identify serum metabolites linking history of GDM to type 2 diabetes (T2D).Methods: Among 2968 parous women in the Hispanic Community Health Study/Study of Latinos, we performed a metabolome-wide association analysis to identify metabolites associated with history of […]

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals. Intended for practicing physicians […]

Introduction and Objective: Prediction of wound healing in DFU is clinically important to stratify risk of amputation and target limb salvage interventions. Basic and clinical studies show both initiation of ulcers and incomplete wound healing arising from reduced tissue perfusion and ischemia due to macro- and microvascular disease. Current vascular diagnostic modalities in clinical practice […]

Introduction and Objective: Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition where insulin resistance and impaired insulin secretion lead to hyperglycemia. Pancreatic β-cells regulate insulin production and secretion; however, pathological stressors encountered during diabetes development, including endoplasmic reticulum (ER) stress, contribute to decreased β-cell mass and function and altered cell identity. The ER […]

Introduction and Objective: Oxidative phosphorylation (OXPHOS) is a hallmark alteration in the diabetic kidney. However, it remains unclear whether this change occurs in kidney-resident macrophages (KRMs) and how this condition contributes to the progression of diabetic kidney disease (DKD).Methods: We investigated OXPHOS-related transcriptomic changes in KRMs within diabetic kidneys using single-cell RNA sequencing data derived […]

Introduction and Objective: People with diabetes and their clinicians spend valuable time on routine visits (RV). Increasing life expectancy among people with diabetes, and an increasing incidence represents a need to restructure outpatient clinics and let technology take care of the RV using remote patient monitoring (RPM). We aim to develop an effective RPM-algorithm to […]

Introduction and Objective: To access the trustworthiness and precision of general-purpose online large language models (LLMs) in providing polycystic ovary syndrome (PCOS) diagnosis-related information.Methods: The present study recruited 125 consecutive women suspected with PCOS in the PCOS subspecialty clinic of Shanghai Tenth People’s Hospital between October 2023 and March 2024, and finally 50 women with […]

Introduction and Objective: Current treatment for obesity and pre-diabetes in older adults includes weight management and engaging in a regular exercise regimen, however, many individuals are unable to achieve success with traditional calorie restriction. Time restricted eating (TRE) is a form of intermittent fasting where individuals eat within a pre-specified daily eating window. Current trials […]