Month: July 2025

Introduction and Objective: The waist circumference-to-body-mass-ratio (W/BMI-Ratio) has attracted interest as a predictor of cardiovascular risk. Its power to predict cardiovascular events in patients with established coronary artery disease (CAD) is not known and is addressed in the present study.Methods: We prospectively recorded cardiovascular events in 1329 patients with angiographically verified coronary artery disease. The […]

Introduction and Objective: Computer vision offers an opportunity to automatically analyze foot images to segment diabetic foot ulcers (DFU) and determine clinically relevant characteristics. Although diabetic foot complications take a disproportionate toll on communities of color, these communities are underrepresented in dermatologic image datasets, which may propagate health disparities. Are current state-of-the-art foot ulcer recognition […]

Introduction and Objective: This study aims to investigate the single and joint effects of T2DM and albuminuria on major cardiovascular events (MACE) in patients with established cardiovascular disease (CVD).Methods: We prospectively investigated 854 patients with CVD (743 with coronary artery disease and 111 with peripheral artery disease) over 9.3±4.5 years. Albuminuria was defined as urine […]

Introduction and Objective: At present, the pathogenesis of T1DM is not completely clear, and more and more studies have shown that CD8+T cells play an important role in the pathogenesis of type 1 diabetes. It has been reported that the signaling lymphocyte activated molecular family (SLAMF) is abnormally expressed in various immune disorders and affects […]

Introduction and Objective: The visceral adiposity Index (VAI) is a reliable biomarker of insulin resistance and is associated with the metabolic syndrome as well as with type 2 diabetes (T2DM). Its power to predict the development of T2DM in patients with established coronary artery disease (CAD) is unclear and is addressed in the presence study.Methods: […]

Introduction and Objective: Obesity is a risk factor for type 2 diabetes (T2D), with weight loss linked to improved glycemic control and reduced disease burden. Obesity medications (OMs) are available to reduce weight and risk associated with T2D, yet misinformation and lack of confidence hinder their use.Methods: In September 2024, Vindico provided the 12th Annual […]

Introduction and Objective: The triglyceride-glucose index (TyG) is a validated biomarker of insulin resistance. Its power to predict major cardiovascular events (MACE) in patients with established cardiovascular disease is unclear and is addressed in the present study.Methods: We enrolled 1790 consecutive patients, 1481 with angiographically proven CAD and 309 with sonographically proven PAD. Prospectively, MACE […]

Introduction and Objective: Nutrition education is vital for managing type 2 diabetes (T2D). For newly diagnosed patients receiving nutrition education, it is hard to determine how much knowledge is retained during that stressful period. We implemented nutrition assessments at the first comprehensive diabetes visit to evaluate baseline nutrition knowledge. We hypothesize that the quizzes will […]

Introduction and Objective: Elevated pro-B type natriuretic peptide (pro-BNP) has been found to be a marker of cardiovascular risk in several high risk populations. However, its power to predict MACE and cardiovascular death in patients with established coronary artery disease (CAD) and non-alcoholic fatty liver disease (NAFLD) is unclear.Methods: We therefore enrolled 568 patients with […]

Introduction and Objective: TERN-601 is a novel once-daily oral small molecule GLP-1 receptor agonist, in development for chronic weight management. This first-in-human (FIH) study evaluated the safety, tolerability, and effect on body weight of TERN-601 in participants with obesity or overweight.Methods: Participants (N=12/cohort) with BMI ≥27 to <40 kg/m2 were randomized 3:1 to receive TERN-601 […]