Month: July 2025

Introduction and Objective: Rare loss-of-function mutations in the DYRK1B gene are associated with early-onset coronary artery disease, metabolic syndrome, and type 2 diabetes.Methods: To investigate its role in metabolism, we generated global Dyrk1b knockout (KO) mice and conducted detailed metabolic and cellular analyses.Results: IPGTT, ITT, and plasma insulin and C-peptide in adult mice revealed impaired […]

Introduction and Objective: Nucleotide-binding oligomerization domain 1 (Nod1), an immune receptor, drives fat-induced insulin resistance. Recent studies show that whole-body and hematopoietic Nod1 knockout (KO) protect against insulin resistance. However, it remains uncertain whether the effect in whole-body KO is due to Nod1 deficiency in macrophages or in extra-macrophage cell(s). Nod1 is expressed in insulin-sensitive […]

Introduction and Objective: Gastric bypass surgery (GB) is a treatment for obesity but alters prandial glycemia, increasing the risk of hypoglycemia. Glucagon administration is a potential therapy for post-GB hypoglycemia, but its effects on prandial glycemia or symptoms remain unclear. We investigated the effect of intravenous (IV) glucagon on prandial symptoms in subjects with and […]

Introduction and Objective: Metabolic dysfunction-associated steatotic liver disease (MASLD) is highly prevalent in people with type 2 diabetes (T2D). MASLD screening is now recommended through calculation of the fibrosis-4 index (FIB4), derived from age, platelet count, AST, and ALT. We evaluated the rate at which these markers were obtained within 2 years for patients with […]

Introduction and Objective: Anxiety, depression, ADHD, and diabetes distress are all associated with adherence issues and risk for poor health outcomes in people with type 1 diabetes (T1D). However, there is limited research assessing youth at time of T1D diagnosis for psychological factors that increase risk for low treatment adherence. Our objective is to assess […]

Introduction and Objective: The International Diabetes Federation suggests replacing the 2-h plasma glucose (PG) ≥200 mg/dL with a 1-h PG ≥209 mg/dL for diagnosing type 2 diabetes (T2D). However, in the Africans in America cohort, the sensitivity of the 1-h PG ≥209 mg/dL threshold was only 67%. Additionally, fasting plasma glucose (FPG) >126 mg/dL alone […]

Introduction and Objective: Transplantation of free islets is limited by the need for systemic immune suppression. To protect transplanted cells from the autoimmune response and avoid the negative effects of systemic immune suppression, which can include damage to remaining and transplanted beta cells, we are developing physical immune-protective hydrogels. We demonstrated good survival and function […]

Introduction and Objective: Glycated hemoglobin (A1C) is widely used in the screening and follow-up of patients with diabetes mellitus (DM), making its accuracy critical for patient care. However, A1C results can be influenced by various factors, including alterations in blood cell counts. This study aimed to evaluate the correlation between hematological abnormalities and inaccuracies in […]

Introduction and Objective: Pediatric obesity rates continue to rise, and with them, comorbidities such as Type 2 diabetes. Transgender youth may be more susceptible to these conditions due to gender- and weight-based stigmatization, increased BMI from gender-affirming therapies, and maladaptive weight management behaviors. Furthermore, current pediatric weight management uses a “one size fits all” approach […]