Introduction and Objective: The visceral adiposity Index (VAI) is a reliable biomarker of insulin resistance and is associated with the metabolic syndrome as well as with type 2 diabetes (T2DM). Its power to predict the development of T2DM in patients with established coronary artery disease (CAD) is unclear and is addressed in the presence study.Methods: We prospectively recorded incident diabetes over 8 years in 918 consecutive non-diabetic Caucasian patients with angiographically proven CAD. Diabetes was diagnosed according to ADA criteria. Prediabetes was identified based on the following parameters: HbA1c levels ranging from 5.7% to 6.4%, fasting plasma glucose concentrations between 100 and 125 mg/dL, or a 2-hour post-oral glucose tolerance test (OGTT) plasma glucose concentration between 140 and 199 mg/dL.Results: At baseline, 63.7% of our non-diabetic CAD patients had prediabetes; the VAI was significantly higher in patients with than in those without prediabetes (1.8±1.4 vs. 2.2±2.3 mg/dl; p=0.017). During follow-up, diabetes was newly diagnosed in 144 patients, i.e. in 15.7% of the study population. The VAI predicted incident diabetes both univariately (OR 1.36 [1.14-1.62]; p<0.001) and after multivariate adjustment including baseline prediabetes (OR 1.19 [1.01-1.40]; p=0.038).Conclusion: We conclude that the incidence of diabetes is high in patients with established CAD and that the VAI strongly and independently predicts the development of diabetes in this population.
T. Plattner: None. A. Vonbank: None. B. Larcher: None. A. Mader: None. L. Schnetzer: None. M. Neyer: None. J. Vogel: None. P. Elsner: None. A. Leiherer: None. A. Muendlein: None. A. Festa: None. H. Drexel: None. C.H. Saely: None.
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