Introduction and Objective: The waist circumference-to-body-mass-ratio (W/BMI-Ratio) has attracted interest as a predictor of cardiovascular risk. Its power to predict cardiovascular events in patients with established coronary artery disease (CAD) is not known and is addressed in the present study.Methods: We prospectively recorded cardiovascular events in 1329 patients with angiographically verified coronary artery disease. The mean follow-up time was 8.7±5.5 years.Results: At baseline, the W/BMI-Ratio did not differ significantly between patients with metabolic syndrome (MetS) and those without MetS (3.6±0.4 vs. 3.6±0.3; p=0.243). Prospectively, the W/BMI-Ratio significantly predicted the incidence of cardiovascular events (n=707) both univariately (standardized HR 1.12 [1.03-1.22]; p=0.006) and after adjustment for age, gender, smoking, LDL-C, HDL-C, hypertension and MetS (standardized adjusted HR=1.10 [1.01-1.21]; p=0.023). The MetS univariately predicted cardiovascular events (1.20 [1.04-1.40]; p=0.014), whereas it did not predict cardiovascular events independently in an adjusted model including the W/BMI-Ratio (HR=1.03 [0.87-1.23], p=0.704).Conclusion: We conclude that the W/BMI-Ratio predicts cardiovascular events beyond the MetS.
T. Plattner: None. A. Vonbank: None. B. Larcher: None. A. Mader: None. L. Schnetzer: None. M. Neyer: None. J. Vogel: None. P. Elsner: None. A. Leiherer: None. A. Muendlein: None. A. Festa: None. H. Drexel: None. C.H. Saely: None.
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