Month: July 2025

Introduction and Objective: To evaluate whether higher engagement with a ​​digital diabetes self-management and education support (DSMES) program + continuous glucose monitoring (CGM) integrated solution is associated with better clinical outcomes through a secondary analysis of a randomized controlled trial.Methods: Participants with type 2 diabetes and HbA1c ≥ 8% not using mealtime bolus insulin (26-83 […]

Introduction and Objective: Type 2 diabetes (T2D) prevalence among U.S. Hispanics exceeds the national average, driven by socioeconomic challenges, genetic predispositions, and limited healthcare access. Variations across subgroups suggest cultural and immigration-related factors may play a role. This study evaluates the association of these factors with T2D and prediabetes among rural Hispanic/Latino adults.Methods: This cross-sectional […]

Introduction and Objective: Chronic Type 2 Diabetes Mellitus (T2DM) is a global health concern, disproportionately affecting African Americans (AA) in the USA. This study investigates gene expression in Amyloid Processing Pathways (APP) and cholesterol biosynthesis-related genes and identifies the key pathways and their roles in linking T2DM to Alzheimer’s Disease (AD) risk in AA.Methods: In […]

Introduction and Objective: Type 2 diabetes mellitus (T2DM) is a major global health concern, significantly increasing the risk of dyslipidemia, which contributes to macrovascular complications. This study aims to explore the correlation between HbA1c levels and lipid parameters in elderly T2DM patients, emphasizing the implications for managing dyslipidemia in this population.Methods: This retrospective cross-sectional study […]

Introduction and Objective: The widely prevalent C variant of SNP rs13266634, encoding an amino acid exchange in the ß-cell specific zinc (Zn) transporter ZnT8, is associated with type 2 diabetes. The relationship between Zn status, ZnT8 genotype at rs13266634, and ß-cell function is underexplored.Methods: Zn concentration in urine samples -uZn, a proxy for Zn status- […]

Introduction and Objective: Heart failure (HF) is common in diabetes and may be asymptomatic in earlier stages. NT-proBNP and BNP [collectively natriuretic peptides (NP)] detect early HF in asymptomatic individuals who could benefit from disease-modifying therapies. We examined the prognostic value of NP levels in people with type 1 (T1D) or type 2 (T2D) diabetes […]

Introduction and Objective: To investigate how β-cell glucose sensitivity, insulin clearance, and insulin sensitivity interact to determine glucose tolerance.Methods: We analyzed data from 54 healthy individuals (age 44 years IQR 27-56, 63% females, BMI 24.5 kg/m² IQR 21.9-28.7, HbA1c 33.26 mmol/mol IQR 32.13-35.51) undergoing a 3-hour OGTT. β-cell glucose sensitivity, insulin clearance, and insulin sensitivity […]

Introduction and Objective: Spasmolytic polypeptide expressing metaplasia (SPEM), which is considered as origin of gastric cancer, is associated with obesity. However, the fundamental determinants and mechanisms underlying obesity-associated SPEM remain poorly understood.Methods: Our metabolomics study analyzed 42 obese patients to assess the association between n-6 polyunsaturated fatty acids (PUFAs) and SPEM. Gastric organoids and mouse […]

Introduction and Objective: Insulin secretion in nondiabetic individuals is inversely related to the prevailing level of insulin sensitivity. The aim of the present study was to characterize insulin secretion caused by GLP-1 RA in non diabetic individualsMethods: 251 subjects free of T2DM received a 2-step hyperglycemic clamp (+125 mg/dl, and +400 mg/dl) followed by intravenous […]

Introduction and Objective: Obesity and T2D remain major health concerns worldwide. We have recently described a centrally acting aminosterol, ENT-03, that induces weight loss in obese and lean rodents. ENT-03 is a synthetic version of the mammalian natural product, which is in Phase 1 clinical trials for treatment of type 2 diabetes and obesity. In […]