Month: July 2025

Introduction and Objective: The incidence of gastrointestinal cancers in type 1 diabetes (T1D) patients is higher than in the general population. This study aimed to explore the association between T1D and gastrointestinal cancer, and how it varies by age and sex.Methods: This retrospective cohort study included 268,179 participants from Korean National Health Insurance Service-National Sample […]

Introduction and Objective: Type 1 diabetes (DM1) is associated with poor sleep quality and increased prevalence of obstructive sleep apnea (OSA), leading to worse glycemic control. We aim to assess the impact of sleep disorders on cardio metabolic markers in DM1.Methods: Our retrospective cross-sectional study included patients with DM1 from our endocrinology clinic who underwent […]

Introduction and Objective: Discrepancy between HbA1c and glucose management index (GMI) is usual but its stability over time is unknown.Methods: We analyzed 386 patients with diabetes (83% type 1) in 10 centers. They had continuous glucose monitoring (CGM) with FreeStyleLibre® 1 or 2 (FSL). For each participant, we specifically collected CGM data over 90 days […]

Introduction and Objective: Mitochondrial Rho-GTPase (MIRO1) is a critical regulator of mitochondrial trafficking and calcium homeostasis and by extension, mediates cellular energy balance and intracellular signaling. This study aimed to mechanistically decipher the role of MIRO1 in modulating skeletal muscle insulin action, which has been completely unexplored.Methods: Skeletal muscle MIRO1 KO mice (MIRO1MKO) and littermate […]

Introduction and Objective: CGM has shown promise as a valuable tool for learning and managing blood glucose levels in persons with non-insulin-treated Type 2 Diabetes (PwT2D). This study investigated the insights PwT2D gain regarding the influence of lifestyle factors on blood glucose levels over a two-week period of CGM usage, with minimal instruction and support.Methods: […]

Introduction and Objective: The difference between cystatin C (cys)- and creatinine (cr)-based estimated glomerular filtration rate (eGFRdiff) is recently documented to be associated with adverse cardiovascular outcomes and diabetes microvascular complications. We examined association between eGFRdiff and carotid plaque score (PS) in patients with type 2 diabetes (T2D).Methods: We enrolled 1,576 patients with T2D. The […]

Introduction and Objective: Urinary C-peptide (UCP) could provide an easily measurable alternative to serum C-peptide (SCP). We aimed (i) to check over-time stability of UCP and (ii) to use UCP to predict homeostasis modelling assessment 2 indices of insulin resistance and beta cell function (HOMA2-IR and -B) and (iii) to be able to assign type […]

Introduction and Objective: Alpha-lipoic acid (ALA) is used for diabetic neuropathy, but their potential impact on macrovascular complications remains unclear. This study aimed to investigate the association between ALA use and the risk of cardiovascular outcomes and mortalityMethods: We conducted a retrospective cohort study using the Korean National Health Insurance Service Health Screening Cohort. Participants […]

Introduction and Objective: Compared to a low caloric Mediterranean diet (LC-med), Very Low Calories Ketogenic Diet (VLCKD) obtains weight loss with a greater caloric deficit and an almost complete carbohydrates restriction that markedly reduces insulin secretion. We compared the impact of VLCKD and LC-med on visceral fat (VAT) and muscle loss.Methods: We studied prospectively 116 […]

Introduction and Objective: Type 2 diabetes (T2D) and obesity are independently associated with increased risk of cardiovascular disease (CVD) and kidney outcomes. This study aimed to explore the impact of body mass index (BMI) at T2D diagnosis on CVD and kidney outcomes, which is less understood.Methods: Data from people diagnosed with T2D from January 2010 […]