Month: July 2025

Introduction and Objective: Overweight/obesity (ow/ob) is increasingly prevalent in T1D, but its impact on vascular complications remains unclear. This study aims to investigate endothelial function in lean (lean T1D) and ow/ob subjects with T1D (T1D+ow/ob), compared to healthy controls.Methods: Endothelial dysfunction was evaluated by flow-mediated dilation (FMD) of the brachial artery and advanced glycation end-products […]

Introduction and Objective: Glycemia management early after liver transplantation (LTx) is challenging due to patients’ critical state and corticoid therapy. We evaluated the impact of actively used real-time continuous glucose monitoring (CGM) on glycemic control in LTx recipients at postoperative ICU in a prospective randomized trial (clinicaltrials.gov NCT05585801).Methods: LTx recipients were randomized to wearing an […]

Introduction and Objective: Coronary artery calcification (CAC), a proxy of atherosclerosis, has increased incidence and prevalence in individuals with diabetes. It is also known that CAC predicts future coronary heart disease, along with mortality in this population. We aimed to evaluate whether the association between diabetes and CAC incidence holds in individuals with diabetes and […]

Introduction and Objective: Inflammation is a key component in the pathogenesis of diabetic peripheral neuropathy (DPN), but underlying mechanisms are poorly understood. We previously identified a nerve-associated macrophage population that responds to neuroinflammatory signaling and expresses the brown adipocyte-related factors beta 3-adrenergic receptor (ADRβ3) and uncoupling protein 1 (UCP1) during tissue regeneration. These studies investigate […]

Introduction and Objective: To evaluate and compare the therapeutic effects of current agents for heart failure with preserved ejection fraction (HFpEF).Methods: Literature retrieval was conducted in PubMed, Embase, the Cochrane Central Register of Controlled Trials and Clinicaltrial.gov between inception and December 2024. Randomized controlled trials (RCTs) in patients with HFpEF, which intercompared current therapeutic agents […]

Introduction and Objective: Recent studies highlight the essential role of amino acids in α cell function, with cysteine (Cys) showing the strongest stimulation of glucagon secretion. Diabetic conditions not only elevate glucagon secretion but also alter plasma Cys levels. Hence, the objective was to decipher the mechanistic role of Cys in modulating α cell function.Methods: […]

Introduction and Objective: This study explored anthropometric indicators to improve body mass index (BMI)’s predictive value for cardiovascular (CV) events in individuals without carotid plaques, improving early risk stratification in subclinical populations.Methods: The study included 1043 participants (aged 50-80) from a 2013-2014 community cohort, followed for CV events (2021-2022). Carotid plaque was excluded using ultrasound. […]

Introduction and Objective: Periodontitis (PD), a chronic inflammatory condition, is a leading cause of tooth loss and jawbone deterioration and is associated with an increased risk of diabetes. The persistent inflammation in PD results from an imbalance between pro-inflammatory (M1) and anti-inflammatory (M2) macrophages, contributing significantly to tissue destruction. This study investigates the role of […]

Introduction and Objective: This study aims to examine the gut and oral microbiome characteristics associated with chronic complications in T1D and explore potential links between these microbiomes.Methods: We conducted a cross-sectional study with 74 T1D patients (disease duration >10 years) and 43 healthy controls. Clinical data such as blood glucose, lipids, and complication-related tests were […]