Introduction and Objective: The catalytic (NKAα1) and auxiliary (NKAβ1) subunits of the NKA protein complex are highly expressed in α-cells, yet their influence is poorly understood. Given the importance of NKA to cation handling and membrane potential regulation, we aimed to define the role of NKA in tuning α-cell Ca2+-handling and glucagon secretion.Methods: Electrophysiology, fluorescence […]
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1339-P: Characterization of HNF1A-MODY in Asia—Mutation Profiles and Clinical Manifestations
Introduction and Objective: MODY is estimated to account for 1-2% of all diabetes cases, with HNF1A-MODY being the most common subtype. While most studies have focused on Europe and North America, this study analyzes HNF1A mutation data and examines the clinical characteristics of Asian individuals with HNF1A-MODY.Methods: We collected data from 38 studies on Asian […]
Read More1655-P: The Effect of Diabetes on Skeletal Muscle Extracellular Matrix and Oxygen Delivery
Introduction and Objective: Type 2 Diabetes (T2D) shortens lifespan largely via increased CVD risk. Cardiorespiratory fitness (CRF), a strong predictor of CVD mortality, is lower in people with T2D. Our previous work showed lower muscle oxidative flux in vivo in T2D compared to overweight controls, despite similar ex vivo mitochondrial oxygen consumption. Supplemental oxygen or […]
Read More1180-P: Regional Grey Matter Volume and Brain Function in Obese Youth with and without Type 2 Diabetes
Introduction and Objective: Emerging evidence demonstrates the presence of neurocognitive impairment and lower brain volume in youth with type 2 diabetes (T2D) and obesity compared to peers. Resting-state functional magnetic resonance imaging (rsfMRI) offers non-invasive assessment of brain function and established brain networks. Multimodal imaging integration, such as brain structure and function, may better elucidate […]
Read More403-P: Evaluating the Effect of Finerenone on Renal Markers in Patients with Diabetic Nephropathy (Stage 1–3) Receiving Angiotensin Receptor Blockers and SGLT2i Therapy
Introduction and Objective: Evaluate the additional role of Finerenone (Fi) on renal markers (RM) in T2DM patients with diabetic nephropathy (DN) Stages 1-3, receiving angiotensin receptors blocker (ARB) [Valsartan {V} or Telmisartan {Tm}], SGLT2i (dapagliflozin) {D} & optimized for Blood Pressure (BP) <130/80mm for at least 1 yr.Methods: Between Oct’ 22 & Mar’ 23, 60 […]
Read More117-OR: Changes in Barriers to Physical Activity in Adults with Type 1 Diabetes—Association with Clinical and Psychological Factors
Introduction and Objective: People living with type 1 diabetes (pwT1D) face barriers to physical activity (PA), such as fear of hypoglycemia, which may evolve over time. This longitudinal study aimed to evaluate changes in barriers to PA and to identify clinical and psychological factors influencing these changes.Methods: Data were obtained from adults pwT1D (≥18 years) […]
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Can the Viral Drink Actually Relieve Stress?
Share on PinterestTikTok users say the “cortisol cocktail” can help lower stress, but experts are skeptical about the benefits. Flashpop/Getty Images Proponents of the viral “cortisol cocktail” claim the drink can reduce stress and improve sleep, but there’s little evidence to support this claim. Its main ingredient, magnesium, may help support stress relief, but the […]
Read More1528-P: Sperm DNA Methylation Is Altered in Men with Type 1 Diabetes
Introduction and Objective: Type 1 diabetes (T1D) can impact reproductive health in males. Given the potential impact of environmental stimuli, including hyperglycemia, on epigenetic marks, we assessed DNA methylation (DNAm) in sperm from men with T1D.Methods: We recruited 29 weight and age-matched men, 19 with T1D and 10 normoglycemic controls (CON). Samples were collected at […]
Read More1149-P: Expanding Access to Continuous Glucose Monitoring in Medicare Patients through Quality Improvement
Introduction and Objective: In 2023, Medicare expanded coverage for continuous glucose monitoring (CGM) to include all patients with diabetes using insulin, but this update has been slow to disseminate to providers. This quality improvement project aimed to improve access to CGM for Medicare patients with type 2 diabetes on insulin at our subspecialty diabetes clinic.Methods: […]
Read More1387-P: Trends and Disparities in Mortality from Comorbid NIDDM and Stroke (1999–2022)—A Retrospective Analysis
Introduction and Objective: Comorbid non-insulin dependent diabetes mellitus (NIDDM) and stroke significantly contribute to mortality among older adults. This study examines age-adjusted mortality rates (AAMRs) and disparities by demographics, region, and age groups to identify trends throughout the period.Methods: Mortality data from CDC records for 55-85+ years were analyzed. AAMRs per 100,000 and annual percentage […]
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