376-P: The Relationship of Mitochondrial DNA Copy Number with Cardiovascular and Microvascular Complications in Patients with Type 2 Diabetes—A Field Substudy

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Introduction and Objective: Mitochondrial dysfunction contributes to cardiovascular and microvascular disease risks in type 2 diabetes (T2D). This study investigates whether mitochondrial DNA copy number (mtDNA-CN) in whole blood can serve as a biomarker for these complications.Methods: mtDNA-CN was measured in the DNA extracted from whole blood samples of 497 T2D adults from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) trial. The relationship of mtDNA-CN with cardiovascular and microvascular complications over 5 years was assessed.Results: The cohort (29.8 % women, mean(SD) age 62(7) years, HbA1c 7.1(1.4)%) showed no variation in mtDNA-CN by sex. There were no significant associations of mtDNA-CN with traditional risk factors of age, BMI, HbA1c, diabetic duration (P>0.05), but mtDNA-CN correlated with eGFR (Pearson r = 0.117, P = 0.009) and plasma uric acid (Pearson r = -0.114, P = 0.012). mtDNA-CN was not related to new on-trial total CVD events, but inversely associated with new on-trial total microvascular events (Table 1).Conclusion: Mitochondrial DNA copy number could serve as a biomarker for assessing microvascular disease risk in T2D patients.

Disclosure

A. Mangani: None. A.S. Januszewski: None. K. Ong: None. H. Francis: None. R.L. O’Connell: None. L. Li: None. D. Sullivan: Other Relationship; Amgen Inc. Research Support; Arrowhead Pharmaceuticals, Inc. Other Relationship; Novartis Pharmaceuticals Corporation, Merck Sharp & Dohme Corp. Research Support; Ionis Pharmaceuticals. R.S. Scott: None. P.G. Colman: None. A. Jenkins: Advisory Panel; Abbott. Speaker’s Bureau; GlaxoSmithKline plc. Research Support; Abbott, Metronics, Ypsomed AG, Insulet Corporation, Jaeb Center for Health Research, Endogenex, Hemsley Charitable Trust. Speaker’s Bureau; CSL Seqirus. Research Support; AbbVie Inc, National Institutes of Health, Juvenile Diabetes Research Foundation (JDRF). A.C. Keech: Research Support; Abbott, Amgen Inc, ASPEN Australia, Mylan. Speaker’s Bureau; Novartis AG, Pfizer Inc. Research Support; Kowa Company, Ltd. Speaker’s Bureau; Sanofi. Research Support; AbbVie Inc, Viatris Inc.

Funding

Laboratoires Fournier, Dijon, France and the National Health and MedicalResearch Council of Australia (457103, 1024105, 1037786, 1105467, 1121272, 1137071 and 2018537)



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