Introduction and Objective: This post hoc analysis assessed the efficacy and hypoglycemia outcomes with once-weekly insulin icodec (icodec) vs once-daily (OD) basal insulin comparators in insulin-naive (ONWARDS 1, 3, 5) and insulin-experienced (ONWARDS 2, 4) adults with T2D by baseline BMI.Methods: Treatment outcomes were analyzed, by trial, across baseline BMI subgroups (<25, ≥25-<30, ≥30-<35, ≥35 kg/m2).Results: Overall, a numerically greater reduction in A1C was seen with icodec vs OD comparators across BMI subgroups in all trials, except for certain subgroups in ONWARDS 4 (basal-bolus trial). There was no statistically significant treatment by BMI subgroup interaction in any trial for change in A1C from baseline to planned end of treatment (EOT) (Figure). Rates of clinically significant or severe hypoglycemia were low across arms irrespective of baseline BMI, except in ONWARDS 4 where rates were overall similar between arms across subgroups. There was no statistically significant treatment by BMI subgroup interaction in any trial for the achievement of A1C <7% at EOT without clinically significant or severe hypoglycemia in the prior 12 weeks.Conclusion: Efficacy and hypoglycemia outcomes for icodec vs OD comparators were overall similar across baseline BMI subgroups.
L.S.S. Canani: Advisory Panel; Novo Nordisk. Speaker’s Bureau; Novo Nordisk. Research Support; Lilly Diabetes, Amgen Inc. A.Y. Cheng: Advisory Panel; Abbott. Speaker’s Bureau; Abbott. Other Relationship; American Diabetes Association. Speaker’s Bureau; Amgen Inc, AstraZeneca. Advisory Panel; Bayer Pharmaceuticals, Inc. Speaker’s Bureau; Bayer Pharmaceuticals, Inc. Advisory Panel; Boehringer-Ingelheim. Speaker’s Bureau; Boehringer-Ingelheim. Advisory Panel; Dexcom, Inc., Eisai, Eli Lilly and Company. Speaker’s Bureau; Eli Lilly and Company, GlaxoSmithKline plc. Advisory Panel; Insulet Corporation. Speaker’s Bureau; Insulet Corporation. Advisory Panel; HLS Therapeutics. Speaker’s Bureau; HLS Therapeutics, Medtronic. Advisory Panel; Novo Nordisk. Speaker’s Bureau; Novo Nordisk, Pfizer Inc. Advisory Panel; Sanofi. Speaker’s Bureau; Sanofi. Consultant; Novo Nordisk, Applied Therapeutics, Vertex Pharmaceuticals Incorporated. J.K. Lindeløv: Employee; Novo Nordisk A/S. Stock/Shareholder; Novo Nordisk A/S, Lundbeck. S.B. Søgaard: Employee; Novo Nordisk. S.M. Vinther: Employee; Novo Nordisk. C. Mathieu: Advisory Panel; Novo Nordisk, Sanofi, Eli Lilly and Company, Abbott, Medtronic, SAB Biotherapeutics, Inc, Roche Diabetes Care, Vertex Pharmaceuticals Incorporated, Biomea Fusion, Bayer Pharmaceuticals, Inc.
Novo Nordisk A/S
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