Discussion The index patient is homozygous for the c.130G>A variant of the INS gene, which most likely fits with the diagnosis monogenic diabetes. To our knowledge, the c.130G>A INS variant presented here has not been described before in a homozygous state. Four patients have been discovered in large-population studies who were heterozygous for the reported […]
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Retrospective derivation of a causal pathway for diabetic ketoacidosis in adult patients with type 2 diabetes mellitus
Results Case data were abstracted from sample of 450 unique adults who had a ß-hydroxybutyrate value ordered and resulted from the ED drawn randomly from a total of 2413 orders. During the same time frame, 1648 patients had a primary diagnosis of diabetes mellitus, hyperglycemia or DKA in the EDs at the four sites. The […]
Read MoreUltra-Processed Foods Linked to Over 124,000 Premature Deaths in U.S.
Share on PinterestA global study linked thousands of preventable deaths to ultra-processed food consumption. Alexander Spatari/Getty Images Ultra-processed foods could be driving an increase in preventable deaths, a global study reports. For every 10% increase in ultra-processed food consumption in total daily energy intake, the risk of all-cause mortality rose by 2.7%. Ultra-processed foods have […]
Read MoreSix months of hybrid closed-loop therapy improves diabetes-specific positive well-being, and reduces diabetes distress and fear of hypoglycemia: secondary analysis of a randomized controlled trial
Discussion In this 26-week, open-label, RCT of HCL versus standard therapy (CSII or MDI without real-time CGM), those allocated to HCL reported significantly greater diabetes-specific positive well-being at 13-week follow-up, which was maintained at 26 weeks. At 26 weeks, the HCL group also reported significantly less frequent perceived unacceptably high glucose levels. Adjusted analyses also […]
Read MoreIs Fluoride in Drinking Water Safe? Here’s What Experts Think
Share on PinterestHealth agencies and experts recommend fluoride in drinking water at low levels (currently 0.7 mg/L in the U.S.) to promote dental health. LukaTDB/Getty Images HHS Secretary Robert F. Kennedy Jr. called for a ban on fluoridated water in U.S. communities. Emerging evidence shows potential health harms and neurotoxic effects in young children, but […]
Read MoreInsulin secretion, sensitivity, and clearance in normoglycemic Black and White adults with parental type 2 diabetes: association with incident dysglycemia
Results Demographic and metabolic variables at baseline A total of 268 adults (145 African American, 123 European American; 193 women, 75 men) who completed baseline assessment of insulin secretion and insulin sensitivity in the POP-ABC study were included in the present analysis (online supplemental figure S1). The participants’ baseline characteristics are shown in table 1. […]
Read More1 Hour of Screen Time at Bedtime Raises Insomnia Risk by 59%
Share on PinterestSpending time on your mobile phone at bedtime can result in poorer-quality sleep and insufficient sleep. MTStock Studio/Getty Images A new Norwegian study finds that one hour of screen time at bedtime results in a 59% higher risk of insomnia and 24 fewer minutes of sleep. The findings indicate that social media use […]
Read MoreSerological markers of exocrine pancreatic function are differentially informative for distinguishing individuals progressing to type 1 diabetes
Discussion We used RF modeling to collectively assess seven T1D-implicated serological markers, in combination with AAbs, GRS2, and demographic information, for their utility in classifying study participants according to AAb/T1D status in a cross-sectional cohort. We observed higher GRS2 values, younger age, and reduced lipase levels associated with ≥2AAb+ versus AAb− classification. While speculative, these […]
Read MoreHow a Stage 4 Diagnosis at 38 Saved This Man’s Life
Share on PinterestWilliam Lindley was diagnosed with stage 4 colon cancer at 38 years old. Image Provided by William Lindley Colorectal cancer is on the rise in people under 50 years old. One man shares his journey of being diagnosed at 38 and the importance of regular screenings. Colonoscopies can detect colorectal cancer early and […]
Read MoreOutcome evaluation and cost-effectiveness analysis for an integrated multidisciplinary diabetic limb salvage program: a combined observational and simulation study
Discussion This study examined the effectiveness of the DEFINITE Care program by comparing clinical outcomes and healthcare utilization over 1 year with a matched historical control cohort. Additionally, we assessed the program’s long-term cost-effectiveness in managing DFUs in a simulated cohort in Singapore over 20 years. This is the first comprehensive study from an Asian […]
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