Category: Diabetes

Introduction and Objective: The aim was to analyze which glycemic parameters predict sleep quality and whether sleep quality predicts psychosocial well-being.Methods: People with type 1 and type 2 diabetes rated their sleep quality daily for 17 days (range: 0-10) on a ecological momentary assessment (EMA) app. CGM was used to calculate %<70 mg/dl (TBR), %>180 […]

Introduction and Objective: Delayed access to insulin (DAI) during pregnancy can have a major impact on effective diabetes management, posing risks to mother and infant. We sought to assess the frequency of DAI (≥ 7 days) in pregnant women and identify associated factors.Methods: Of 1262 pregnant women aged ≥18 with GDM or pre-existing T2DM who […]

Introduction and Objective: Behavioral Family Systems Therapy for Diabetes (BFST-D), a family-based pediatric psychosocial type 1 diabetes (T1D) intervention, improves glycemic levels and family conflict. A brief group-based version of bBFST-D has evidence of effectiveness. However, few families receive this care. Using evidence-based quality improvement (EBQI), the current study aimed to develop and tailor a […]

Introduction and Objective: Non-alcoholic steatohepatitis is a prevalent metabolic liver disease with limited therapeutic options. This study aimed to investigate the therapeutic potential of intestinal epithelial organoid (IEO)-derived exosomes in treating steatohepatitis.Methods: IEOs were generated from the small intestinal tissue of eight-week-old C57BL/6 mice, and exosomes were isolated from IEO culture supernatants. Human hepatoma HepG2 […]

Introduction and Objective: Evidence-based pediatric psychosocial type 1 diabetes (T1D) care improves child (glycemic levels, diabetes distress) and family (conflict) health outcomes. However, few intervention studies have included substantial proportions of African American or low income families of any race. This community-engaged study aimed to identify strategies to increase engagement of these families in T1D […]

Introduction and Objective: This study aims to determine the minimum weight loss required for diabetes prevention in the Korean population.Methods: The Korean Diabetes Prevention Study (KDPS), a prospective, multicenter, randomized controlled trial, enrolled prediabetic adults aged 30-70 with a body mass index ≥23 kg/m2 from 2016 to 2022. Participants were assigned to standard management, lifestyle […]

Introduction and Objective: Substance use (SU) and SU disorders (SUDs) adversely affect diabetes management and increase the risk of diagnosed diabetes (DM) complications. We estimated disparities in the prevalence of SU, SUDs, and SUD treatment among those with SUDs (SUDT) among US adults with DM by sociodemographic characteristics.Methods: We used 2021-2022 National Survey on Drug […]

Introduction and Objective: β cell dysfunction is the driving force of type 2 diabetes mellitus (T2DM) pathogenesis. SIRT7 is an NAD+-dependent lysine deacetylase with diverse functions in glucose metabolism. However, its role in islet remains uncharacterized. Here, we explored the functional role of SIRT7 in β cell physiology and pathophysiology.Methods: We generated Sirt7 β cell […]

Introduction and Objective: Reducing loneliness and lack of social and emotional support (LSES) among adults with diabetes (DM) can improve diabetes management and health outcomes. Considering the distinct pathophysiology and risk factor profile of each diabetes type, we explored the prevalence of loneliness and LSES among adults with type 1 or type 2 DM using […]

Introduction and Objective: Comprehensive telehealth improves control of refractory chronic diseases in integrated health systems, but has seldom been implemented in fee-for-service (FFS) systems. We examined the use of comprehensive telehealth for uncontrolled T2D and hypertension in a FFS environment.Methods: This randomized effectiveness-implementation trial compared two 12-month mobile monitoring-enabled telehealth interventions: 1) a self-management program; […]