Category: Diabetes

Introduction and Objective: Fibroblast growth factor 21 (FGF21) is a hepatokine with potential therapeutic relevance in diabetes, as it modulates glucose and lipid metabolism and suppresses sugar preference. However, depression, which is common in older adults, is associated with higher sucrose preference, especially in women, and its impact on FGF21’s metabolic effects remain unclear. We […]

Introduction and Objective: The critical role of innate immune activation leading to inflammatory events in the body has become of much interest and investigation in recent times because of its strategic importance in diabetes pathophysiology. Therefore, therapeutic targeting of innate immune activation may provide a new approach to treatment/management of diabetes. Carnosine is a physiological […]

Introduction and Objective: Hispanic/Latino adults in Puerto Rico experience one of the highest type 2 diabetes (T2D) prevalence rates in the US and an elevated risk of mild cognitive impairment and dementia, contributing to significant health disparities. Prior studies report biological sex differences in the T2D-cognition association with implications for tailoring interventions, but few have […]

Introduction and Objective: We explored whether and how depressive symptoms in youth and young adults (YYA) with youth-onset type 1 diabetes (T1D) mediate the effects of household food insecurity (HFI) on hemoglobin A1c (HbA1c).Methods: Cross-sectional data from the SEARCH for Diabetes in Youth Study (2016-2019) included 1,093 YYA with T1D. We applied causal mediation modeling […]

Introduction and Objective: Understanding factors associated with C peptide (CP) preservation in type 1 diabetes (T1D) may aid interventions in the partial remission period. Fasting and stimulated CP or urinary CP to creatinine ratio (UCPCR) measure residual beta cell function.Methods: We utilized home monitoring CP collection with volumetric absorptive microsampling (VAMS) and a simplified mixed […]

Introduction and Objective: Risk of unstable plaques, noted by reduced content of vascular smooth muscle cells (VSMC) and extracellular matrix (ECM), with elevated inflammatory cells and necrosis, are increased in diabetes for unknown reasons. This study investigated the role of insulin in VSMC and the formation of unstable plaques.Methods: Insulin receptor (IR) knockout and VSMC […]

Introduction and Objective: Children with T1DM may experience alterations in growth. The aim was to compare growth trajectories assessed by z-Height and z-BMI over three years between children with new-onset T1DM and a control group without T1DM across multiple Latin American centers.Methods: In a retrospective analysis of medical records, age, sex, and anthropometric measures were […]

Introduction and Objective: The 2nd meal phenomenon refers to the improved glycemic response observed after consuming a 2nd identical meal. It is well known that postprandial hepatic glucose uptake (HGU) is determined by the combined effects of three regulatory factors: insulin action (hyperinsulinemia; HI), glucose effectiveness (hyperglycemia; GE), and glucose delivery into the hepatoportal circulation […]

Introduction and Objective: We implemented Disordered eating behaviors (DEB) screening in adolescents with type 1 diabetes (T1D) using the Diabetes Eating Problem Survey-Revised (DEPS-R) tool as recommended by the American Diabetes Association. We aim to highlight the prevalence of DEB in adolescents with T1D along with the relationship with technology use.Methods: Retrospective chart review of […]

Introduction and Objective: Cardiovascular disease (CVD) is the leading cause of death in the US. The i3C risk score is the only predictive model of 35-year fatal/non-fatal cardiac events in adolescents and young adults (AYA), but its reliability is unknown. We evaluated the i3C score test-retest reproducibility over short and long-term intervals.Methods: In a pooled […]