Category: Diabetes

Introduction and Objective: At present, the pathogenesis of T1DM is not completely clear, and more and more studies have shown that CD8+T cells play an important role in the pathogenesis of type 1 diabetes. It has been reported that the signaling lymphocyte activated molecular family (SLAMF) is abnormally expressed in various immune disorders and affects […]

Introduction and Objective: The visceral adiposity Index (VAI) is a reliable biomarker of insulin resistance and is associated with the metabolic syndrome as well as with type 2 diabetes (T2DM). Its power to predict the development of T2DM in patients with established coronary artery disease (CAD) is unclear and is addressed in the presence study.Methods: […]

Introduction and Objective: Obesity is a risk factor for type 2 diabetes (T2D), with weight loss linked to improved glycemic control and reduced disease burden. Obesity medications (OMs) are available to reduce weight and risk associated with T2D, yet misinformation and lack of confidence hinder their use.Methods: In September 2024, Vindico provided the 12th Annual […]

Introduction and Objective: The triglyceride-glucose index (TyG) is a validated biomarker of insulin resistance. Its power to predict major cardiovascular events (MACE) in patients with established cardiovascular disease is unclear and is addressed in the present study.Methods: We enrolled 1790 consecutive patients, 1481 with angiographically proven CAD and 309 with sonographically proven PAD. Prospectively, MACE […]

Introduction and Objective: Nutrition education is vital for managing type 2 diabetes (T2D). For newly diagnosed patients receiving nutrition education, it is hard to determine how much knowledge is retained during that stressful period. We implemented nutrition assessments at the first comprehensive diabetes visit to evaluate baseline nutrition knowledge. We hypothesize that the quizzes will […]

Introduction and Objective: Elevated pro-B type natriuretic peptide (pro-BNP) has been found to be a marker of cardiovascular risk in several high risk populations. However, its power to predict MACE and cardiovascular death in patients with established coronary artery disease (CAD) and non-alcoholic fatty liver disease (NAFLD) is unclear.Methods: We therefore enrolled 568 patients with […]

Introduction and Objective: TERN-601 is a novel once-daily oral small molecule GLP-1 receptor agonist, in development for chronic weight management. This first-in-human (FIH) study evaluated the safety, tolerability, and effect on body weight of TERN-601 in participants with obesity or overweight.Methods: Participants (N=12/cohort) with BMI ≥27 to <40 kg/m2 were randomized 3:1 to receive TERN-601 […]

Introduction and Objective: The power of cardiovascular risk prediction is biased by comorbidities (e.g. metabolic syndrome, MetS), medical treatment, and age, which impact cholesterol levels. When applying LDL-C, the true risk of such confounded patients is often underestimated. However, it is unclear whether this likewise applies to other lipid markers, in particular ceramides.Methods: In this […]

Introduction and Objective: Aging is associated with the declination of β-cell function in type 2 diabetes. However, the precise mechanisms underlying the functional changes in β cells due to aging remain unclear. In this study, we investigated the changes in β-cell functions associated with aging.Methods: We cultured islets from young (7 weeks of age) and […]

Introduction and Objective: Fibroblast growth factor 21 (FGF21) is a hepatokine with potential therapeutic relevance in diabetes, as it modulates glucose and lipid metabolism and suppresses sugar preference. However, depression, which is common in older adults, is associated with higher sucrose preference, especially in women, and its impact on FGF21’s metabolic effects remain unclear. We […]