Introduction and Objective: Children with T1DM may experience alterations in growth. The aim was to compare growth trajectories assessed by z-Height and z-BMI over three years between children with new-onset T1DM and a control group without T1DM across multiple Latin American centers.Methods: In a retrospective analysis of medical records, age, sex, and anthropometric measures were collected over three years (2021-2024) in children with T1DM onset and their controls from ten Latin American centers. A mixed-effect model was used to analyze z-height and z-BMI over three years.Results: The study involved 534 children (48.3% F) aged 8.4 y, comprising 245 with T1DM onset and 289 controls. Children with T1DM had a significantly lower z-BMI than controls, with mean differences of -0.71, -0.33, and -0.28 in years 0, 1, and 2, respectively. However, by year 3, the difference (-0.18) was no longer significant. While the z-height of the controls remained stable over time, the T1DM group experienced a sharp decline, resulting in a significantly lower z-height (-0.25) in year 3.Conclusion: Our z-BMI findings indicate that diagnostic delay may still affect children with T1D in Latin America, while our z-Height findings indicate that even with treatment and equalization of z-BMI, children with T1D in Latin America experience some growth retardation compared to their peers.
V. Hirschler: None. C. Molinari: None. D.R. Witte: None.
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