Introduction and Objective: Prediabetes (PreD) and type 2 diabetes (T2D) are increasingly common in young adulthood, a period of declining physical activity (PA). We investigated associations between individual- and community-level social determinants of health (SDOH) and PA in young adults with and without PreD or T2D.Methods: We conducted a cross-sectional study using survey and Fitbit […]
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1353-P: Asymptomatic Individuals with β-Thalassemia Trait in Southern China Having Falsely Low Hemoglobin A1c Levels Are Readily Identified by Their Low MCV, Low MCH, and High RDW Values
by sugaradmin
Introduction and Objective: Testing HbA1c in undiagnosed asymptomatic thalassemia traits/carriers in prevalent regions can be problematic because HbA1c values may falsely be altered, potentially leading to inappropriate management.Methods: This cross-sectional study evaluated 397 individuals who underwent annual health screening and thalassemia genetic testing in a tertiary care hospital. Of this cohort, 85 iron-deficient and 16 […]
Read More681-P: Medication Adherence in the Glycemia Reduction Approaches in Diabetes—A Comparative Effectiveness (GRADE) Study
by sugaradmin
Introduction and Objective: We examined medication adherence as a predictor of glycemic outcomes and evaluated treatment group differences in the GRADE study.Methods: GRADE participants (T2DM <10 years, HbA1c = 6.8-8.5%, on metformin monotherapy) were randomly assigned to add insulin glargine, glimepiride, liraglutide, or sitagliptin. The Emotional Distress Substudy followed 1,739 participants who self-reported adherence to […]
Read More1352-P: Among Those with Normoglycemia (NG), Insulin Resistance Risk Score (IRRS) Elevation Is Observed Up to Three Years prior to Diagnosis of Diabetes (T2D) or Prediabetes (PD)
by sugaradmin
Introduction and Objective: The prevalence of PD and T2D has been steadily increasing. Thus, early risk markers for PD and T2D in individuals with NG are critically important. We asked whether Insulin Resistance Risk Score (IRRS) could be an early risk marker for future PD or T2D.Methods: Individuals with NG (FPG <100 mg/dL and HbA1c […]
Read More848-P: The Antidiabetic Medication Treatment Patterns in Chinese Patients with Type 2 Diabetes—Real-World Evidence from ICaReMe China Registry Study
by sugaradmin
Introduction and Objective: The global prevalence of type 2 diabetes mellitus (T2DM) is widely recognized to be on the rise. It is of great significance to reveal the current status of antidiabetic therapy in patients with T2DM.Methods: “Real-world Multicenter Registry to Determine Management and Quality of Care of Patients With Type 2 Diabetes in China” […]
Read More1351-P: New-Onset Hyperglycemia in COVID-19—An Indian Perspective on Clinical Outcomes and Management
by sugaradmin
Introduction and Objective: Hyperglycaemia has emerged as a significant complication in COVID-19, particularly in India, where the prevalence of diabetes is high. The objective of this study was to determine the prevalence, clinical manifestations, severity, and outcomes of new-onset hyperglycaemia in COVID-19 patients without pre-existing diabetes.Methods: A retrospective observational study was conducted on 2750 hospitalised […]
Read More843-P: A Novel CRFR2 Selective UCN2 Analog, HM17321, Facilitates Weight Loss and Improves Body Composition across Animal Models of Obesity
by sugaradmin
Introduction and Objective: Incretin drugs effectively promote weight loss, but also cause inevitable lean mass loss, compromising weight loss quality (WLQ). Urocortin-2 (UCN2) shows potential for enhancing lipolysis and muscle hypertrophy, offering a strategy to improve WLQ. To achieve these outcomes, a novel corticotropin-releasing factor receptor-2 (CRFR2) selective UCN2 analog, HM17321, was developed. The present […]
Read More1350-P: Community-Supported Initiative for Diabetes Screening and Management in a Rural Community in Bangladesh
by sugaradmin
Introduction and Objective: This study aimed to evaluate the feasibility of a community-supported initiative for diabetes screening and management in a rural community in Bangladesh.Methods: Our community-supported initiative comprised design ethnography to understand the community and identify local resources. Then, community organization was facilitated by forming a health and inclusion committee after obtaining approval from […]
Read More196-OR: The Global Loss of DYRK1B Impairs Glucose Tolerance by Disrupting Beta-Cell Development and Function
by sugaradmin
Introduction and Objective: Rare loss-of-function mutations in the DYRK1B gene are associated with early-onset coronary artery disease, metabolic syndrome, and type 2 diabetes.Methods: To investigate its role in metabolism, we generated global Dyrk1b knockout (KO) mice and conducted detailed metabolic and cellular analyses.Results: IPGTT, ITT, and plasma insulin and C-peptide in adult mice revealed impaired […]
Read More134-OR: NOD1 Deletion in Skeletal Muscle Protects against Palmitate-Induced Insulin Resistance
by sugaradmin
Introduction and Objective: Nucleotide-binding oligomerization domain 1 (Nod1), an immune receptor, drives fat-induced insulin resistance. Recent studies show that whole-body and hematopoietic Nod1 knockout (KO) protect against insulin resistance. However, it remains uncertain whether the effect in whole-body KO is due to Nod1 deficiency in macrophages or in extra-macrophage cell(s). Nod1 is expressed in insulin-sensitive […]
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