Category: Diabetes

Introduction and Objective: To investigate the potential of metoclopramide, a dopamine antagonist, in restoring impaired hypoglycemic counterregulation in a diabetic animal model.Methods: Diabetes was induced in 10-week-old Sprague-Dawley rats with streptozotocin (STZ, 65 mg/kg IP). Rats were randomized into three groups: 1) diabetic controls treated with recurrent saline (DRS, n=6), 2) diabetic rats preconditioned with […]

Introduction and Objective: Sustainable quality improvement in diabetes care remains challenging in resource-constrained health systems, where time and staffing often limit feasibility. This study evaluated whether a minimally time-consuming, continuously applied monitoring approach could support sustained glycemic improvement and guide data-informed interventions in a rural diabetes education program.Methods: Retrospective pre-post analyses were conducted on monthly […]

Introduction and Objective: Timely glycemic control reduces the risk of diabetes complications. This study evaluated whether initiating FreeStyle Libre (FSL) was associated with faster achievement of A1C targets (6.5%, 7%, and 8%) than no continuous glucose monitoring (CGM) in non-insulin treated adults with type 2 diabetes (NIT2D).Methods: Using Truveta electronic health record data, adults (≥ […]

Introduction and Objective: Metformin taken during pregnancy crosses the placenta. In vitro, it has robust metabolic stress effects in fetal hepatocytes. We hypothesized that metformin exposure in utero would disrupt oxidative metabolism and produce hepatocellular injury in the fetal liver, a major site of uptake.Methods: Pregnant Rhesus macaques received vehicle (VEH), or metformin (MET) and […]

Introduction and Objective: Despite benefits of modern diabetes (DM) care, population-level glycemic control has not improved, especially among groups often marginalized from traditional care due to socioeconomic and cultural factors.Methods: The DICHA (DM In Control for Hispanics through an Alliance) program is a 6-month enhanced primary care model for Latino people with diabetes (LPWD) that […]

Introduction and Objective: Small-molecule DYRK1A inhibitors such as harmine stimulate adult human β-cell proliferation; however, only a subset enhances β-cell identity/function. We sought to define the signaling mechanism underlying this phenotype, determine whether it is a class effect or requires DYRK1A inhibition, and identify the responsible pathway in human β-cells.Methods: Primary human islets and R7T1 […]

Introduction and Objective: T2D increases the risk of clinical outcomes in MASH cirrhosis. This post hoc analysis assessed changes in liver disease and insulin sensitivity in participants with baseline T2D and compensated cirrhosis due to MASH in the SYMMETRY trial of efruxifermin.Methods: SYMMETRY (NCT05039450) is a phase 2b, randomized, placebo-controlled trial that evaluated efruxifermin QW […]

Introduction and Objective: Older adults with type 1 diabetes face age-related changes. Dyadic coping, where care partners (CPs) and people with diabetes (PWD) collaboratively manage diabetes, can improve outcomes but is hindered by misaligned illness appraisals (viewing diabetes as individual vs. shared responsibility) and communication difficulties. This study describes experiences of older PWD/CP dyads in […]

Introduction and Objective: HZ has been associated with a higher risk of cardiovascular events, but evidence in T2DM is limited. This analysis assessed associations between HZ and MI/IS in older adults with T2DM.Methods: Using US administrative claims and EHR data (Optum Market Clarity, 2016-2024), adults with T2DM and HZ were identified by ICD-10 diagnosis codes. […]

Introduction and Objective: Type 1 diabetes cell therapies aim to restore normoglycemia by replacing lost beta cells, but low clinical supply and the need for chronic immune suppression are key challenges. CNTY-813 overcomes these challenges via clinical-scale production of Allo-Evasion™ 5.0-engineered iPSC-derived beta islets that are engineered for immune evasion. Thus, CNTY-813 provides an off-the-shelf, […]