Category: Diabetes

Introduction and Objective: Ferroptosis of renal tubular epithelial cells (RTECs) is implicated in the pathogenesis of diabetic kidney disease (DKD). Bardoxolone methyl (BM), a synthetic triterpenoid with antioxidant and anti-inflammatory properties, has shown promise in clinical trials for preventing DKD-related renal decline but carries a risk of heart failure. Recent studies revealed that 2-deoxy-D-ribose (dRib) […]

Introduction and Objective: In a Phase III, randomized, placebo-controlled, multi-center study in which T2DM patients were treated with oral insulin for 26 weeks, the primary endpoint defined as a decrement of 0.6% HbA1c by end of treatment was not met. A post-hoc analysis aimed to identify subpopulations with substantial clinical responses to treatment.Methods: Explainable AI […]

Introduction and Objective: Diabetes and adipose research generate rich datasets whose accessibility and integration are often limited. To address this challenge, we created the Mammalian Adipose Tissue Knowledge Portal (MATKP; matkp.org), an open community portal for multi-species mammalian adipose biology. MATKP is accessible to diverse users and aggregates data for adipose tissues and cell types, […]

Introduction and Objective: HCL is the preferred insulin delivery method for people with T1D, however mealtime carbohydrate counting limits benefit. Use of AI to implement automated insulin delivery (AID) algorithms, able to avoid mealtime interactions, could alleviate burden and broaden use. We tested the latest UVA AID neural network-based system (AIDANET) in FCL in a […]

Introduction and Objective: There is a paucity of objectively measured physical activity (PA) data in underserved populations. We examined objectively measured and self-reported PA among Chinese immigrants with type 2 diabetes (T2D) in NYC.Methods: We analyzed baseline data from 60 participants. PA was measured by a wrist-worn ActiGraph GT9X accelerometer and the International Physical Activity […]

Introduction and Objective: Automated insulin delivery (AID) systems adjust insulin delivery based on real-time glucose readings, offering potential advantages over open-loop insulin delivery (OLID). Ramadan fasting presents unique challenge for individuals with type 1 diabetes (T1D) due to significant fluctuations in glucose levels. This study aimed to identify the predictor factors associated with achieving better […]

Introduction and Objective: The Planetary Health Diet (PHD), introduced in 2019 by the EAT-Lancet Commission, promotes chronic disease prevention and environmental sustainability. However, evidence on PHD adherence and its association with type 2 diabetes (T2D), cardiovascular disease (CVD), and weight gain is scarce, especially among women with a history of gestational diabetes mellitus (GDM).Methods: We […]

Introduction and Objective: Automated insulin delivery (AID) systems, adjusting insulin based on real-time glucose readings, may offer advantages over open-loop insulin delivery (OLID), especially during Ramadan fasting, which poses challenges for individuals with type 1 diabetes (T1D).Methods: This dual-center, open-label, randomized controlled trial compared AID systems (Medtronic MiniMed 780G [M780] and Tandem T-slim Control IQ […]

Introduction and Objective: Oxytocin has been proposed to have anorexigenic effects and the gene is among the most upregulated in the small intestine after Roux-en-Y gastric bypass (RYGB) surgery. We evaluated oxytocin and oxytocin receptor gene expression along the intestinal tract in individuals with and without type 2 diabetes, and assessed circulating concentrations of the […]

Introduction and Objective: Hybrid closed-loop (HCL) therapy has revolutionized the care for people living with type 1 diabetes (pwT1D). The integration of different technology devices evolves rapidly providing individuals with more options and flexibility. We aimed to assess real-world outcomes of the new HCL system integrating the tubeless Omnipod 5 insulin pump with FreeStyle Libre […]