Share on PinterestA new study found that smoking cannabis before drinking led participants to drink less. Aaron McCoy/Getty Images Smoking cannabis before drinking can significantly curb how much people choose to drink, according to new research. It’s unclear how the findings would translate to real-world scenarios outside of a lab environment. The long-term risks and […]
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This issue will review: 1. Screening Natriuretic Peptide Levels Predict Heart Failure and Mortality in Individuals with Type 1 and Type 2 Diabetes without Known Heart Failure 2. The Risk of Acute Pancreatitis and Biliary Events After Initiation of Incretin-Based Medications In Patients with Type 2 Diabetes 3. Continuous Glucose Monitoring Frequency and Glycemic Control […]
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Share on PinterestA regular bedtime may be a simple, low risk, adjunctive strategy for blood pressure management. DragonImages/Getty Images Researchers report that a regular bedtime schedule can help lower a person’s blood pressure. High blood pressure can increase the risk of heart disease, stroke, vision loss, and kidney disease. Quality sleep can be attained with […]
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Share on PinterestEven occasional smoking can significantly raise heart disease risk. Mal de Ojo Studio/Stocksy Researchers say that smoking as few as two cigarettes a day can significantly increase a person’s risk of heart disease. Experts say there is no safe level of smoking, and the best preventive strategy is to never start the unhealthy […]
Read MoreBy stimulating hepatic glucose production, glucagon (released by islet α-cells) restores normal blood glucose levels when they fall below the normal range. We used optogenetics in conjunction with electrophysiology, cytoplasmic free Ca2+ concentration imaging, and hormone release measurements to explore the intrinsic and paracrine regulation of glucagon secretion. Many α-cells were spontaneously active at 1 […]
Read MoreThe primary treatment for obesity involves calorie restriction (CR) to promote dietary weight loss achieved through interventions including behavioral modification, bariatric surgery, and antiobesity medications. In adults with obesity, CR-induced weight loss enhances physical function and improves quality of life, while also reducing the burden of various obesity-related chronic conditions, including hypertension, diabetes, obstructive sleep […]
Read MoreTreatment responses to behavioral, surgical, and pharmacological approaches in obesity are highly variable in quantity and quality. Here we refer to high-quality weight loss as a high proportion of fat to skeletal muscle mass lost. Given the role of skeletal muscle in energy expenditure, glucose homeostasis, metabolic flexibility, mobility, and strength, excessive loss of skeletal […]
Read MoreSarcopenic obesity, a subtype of obesity, is marked by reduced skeletal muscle mass and function, or sarcopenia, and poses a significant health challenge to older adults as it affects an estimated 28.3% of people aged >60 years. This subtype is unique to older adults as aging exacerbates sarcopenia and obesity due to changes in energy […]
Read MoreUntil recently, the prevalence of endogenous Cushing syndrome has been considered to be low. However, improved diagnostic strategies and increased awareness have broadened our understanding of hypercortisolism and its role in the pathophysiology of type 2 diabetes, obesity, hypertension, and cardiovascular disease. Recent studies from Europe, South America, and the U.S. have demonstrated that a […]
Read MoreRibosome profiling (Ribo-seq) measures translational regulation and reveals novel or unannotated open reading frames (nuORFs) otherwise difficult to identify. Recent reports demonstrate that nuORFs regulate gene expression and immune recognition, highlighting their emerging biological roles. Pancreatic β-cells are critical for maintaining euglycemic conditions, and β-cell impairment contributes to diabetes development. Identification of nuORF and protein/peptide […]
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