Author: sugaradmin

Metabolic and energy reprogramming, potentially regulated by protein lipoylation, plays a critical role in maintaining kidney function and cell survival in diabetic kidney disease (DKD). However, it remains unclear whether improper reprogramming contributes to the onset of DKD. To investigate this issue, we developed a group of metabolic mouse models with varying levels of protein […]

Recent clinical trials testing glucagon-like peptide-1 receptor agonists (GLP-1 RAs) demonstrated improved outcomes in obesity-associated complications, including cardiovascular events and hepatic steatosis. Despite their positive effects, whether the benefits of GLP-1 RAs are due to weight loss or are a direct therapeutic effect remains unclear. Therefore, we pair fed middle-aged low-density lipoprotein receptor knockout (Ldlr−/−) […]

Type 1 diabetes results from the immune-mediated loss of insulin-producing pancreatic islet β-cells, rendering those affected dependent on exogenous insulin to survive. Despite the array of choices available for insulin delivery, treatment to maintain near-normal glucose metabolism while avoiding hypo- and hyperglycemia remains a challenge. After two decades of clinical trials across four continents, the […]

Obesity is a major risk factor for the development of type 2 diabetes (T2D). While the connection between these two disease entities is still incompletely understood, even modest weight loss can greatly reduce the risk of developing T2D and its sequelae. With the recent success of antiobesity pharmacotherapies, which appear to exert their effects largely […]

The current study examined the effect of empagliflozin on hepatic glucose production (HGP) and total-body norepinephrine (NE) turnover in individuals with and without type 2 diabetes (T2D). The study randomized 36 individuals with T2D and 36 individuals without T2D to receive in a double-blind fashion empagliflozin or matching placebo (2:1 ratio) for 12 weeks. HGP […]

Issues and Events Source link

In the Pennines, a range of moorland hills in northern England, it rains for much of the year. “The grass grows very green, very long, and as a consequence, the cows produce a lot of milk,” David Hodson says. As a kid growing up in this farmland outside of Manchester, Hodson always saw the livestock […]

Gestational diabetes mellitus affects almost 18 million pregnancies worldwide, increasing by >70% in the past 20 years. DNA methylation has been associated with maternal hyperglycemia and type 2 diabetes risk in offspring. This study hypothesized that hyperglycemia during pregnancy influences DNA methylation changes at birth that mediate metabolic risk in offspring. Cord blood samples (n […]

Deutsches Zentrum för Diabetesforschung10.13039/100031584 Source link

Diabetes UK10.13039/50110000036119/000610822/0006452Breakthrough T1D3-SRA-2024-1583-S-B3-SRA-2024-1584-S-BThe Leona M. & Harry B. Helmsley Charitable TrustG-2203-05808RFP-S-701991-5021-001 Source link